[Lotus]

 

growth hormone (GH) stimulates IGF-1, but IGF-1 oddly enough reduces GH.....the pituitary GH signal is immediate, while liver GH is slow to process...and takes longer to exit the liver.

However, E2 and GH are like best buddies, they can stimulate IGF-1, and that's the part that intrigues me the most. I've come to realize that taking breast growth to the next level means duplicating growth spurts (or mini cascades if you will).....mirroring that growth spurt's in puberty  and pregnancy. So...HPG->E2 -> GH -> IGF-1 -> inhibit somatostatin -> EOP (endogenous opioid peptides)....these actions occurs only in pubety.....our goal is to prove that hypothesis wrong, we will find little known pathway(s) and it's appropriate synthesis for our needs....without using steroids....and improving nitrogen loss.

GH / IGF-1 (growth hormones) with estradiol, that combination helps developed TEB's (terminal end buds)....in other words the essential part of mammary ductal system. GH improves estrogen receptors, like taking L-arginine, Glutamine, Glycine and a few others up-regulates GH. And btw, developing TEB (terminal ends buds are likely the first stage of breast growth in puberty), though I believe you can still grow (or mature) TEB's in adulthood.

wish us luck.