21-10-2016, 10:39 PM
women metabolize quicker, PM drastically changes menstrual cycles. Ella is right, look at the evidence in breast nexus archives. NO ONE should take 4000mg of PM.
(14-01-2016, 11:54 PM)Lotus Wrote:Quote:Clinical studies indicate that women metabolise drugs which are substrates of CYP3A4 more quickly than men (20–30% increase)4. Analysis has shown around two fold higher levels of CYP3A4 protein in female compared to male tissue samples3,4. http://www.medsafe.govt.nz/profs/PUArtic...4503A4.htm
So, in other words we can't simply suggest someone else should take x amount of an herb/med without some research done by the individual. The swing in metabolism could be as much as 50% in individuals. As I said before, if the PM is legit, females should only take 100 to 250 mg......and only in the first half. What PM does in the brain (especially in females) is less understood. Meaning, how PM effects the HPA (hypothalamus pituitary axis) is tricky business, and especially at growth hormones/ lutenizing & follicle stimulating hormones, which (will) causes everyone to metabolize differently.
