[Lotus]

I've been looking into activating fatty tissues in breasts through a specific enzyme, which btw we (humans) have about 10,000 different enzymes, lol.

Also, we should be focused on the anatomy of the Breast and how we can influence it, i.e. each breast contains about 20 lobes, fatty tissue, oh yeah, and pectoral muscles. (Goal-build muscle and tissue)

Estrogen receptors of: ER-α (alpha), prolactin receptor, and progesterone receptor are in mammary glands.
Agonist hormones activate those three estrogen receptors, and (usually) cause cell proliferation. It is uncertain what the function of herbs known for weight loss, that have agonists, do. Androgenic hormones are antagonists (against) to those.
ER-β (estrogen receptor-beta) is not generally in breast tissue.

I've come across so much conflicting info on PM, some of the research interpreted is misstated, for example, and I won't list where from but it was stated that miroestriol was 70% of E2, when actually it was from below*. Anyways we've only found it to be .25 of E2, although Dexymiroestrol is stated to be 10-fold greater potency in an MCF-7 cell assay relative to Miroestrol. It's also been reported that Dexy and miroestriol has effects on both receptors and that it's only influence and what makes PM active is its other phytoestrogens. And we have the studies that profess that soy has no estrogenic effect at all.

* MAMMOGENIC ACTIVITY OF MIROESTROL
http://joe.endocrinology-journals.org/co.../401.short


Down regulation of gene related sex hormone synthesis pathway in mouse testes by miroestrol and deoxymiroestrol
http://www.ncbi.nlm.nih.gov/pubmed/21856387


Bimodal action of miroestrol and deoxymiroestrol, phytoestrogens from Pueraria candollei var. mirifica, on hepatic CYP2B9 and CYP1A2 expressions and antilipid peroxidation in mice
http://www.nrjournal.com/article/S0271-5...ack-bb0045

(Credit Denita)

1) In addition to miroestrol and deoxymiroestrol, Pueraria Mirifica also contains other chemicals that belong to isoflavones and Coumestan groups of phyto-estrogens, e.g.,

• Genistein,
  
• Daidzein,
  
• Daidzin,
  
• Genistin,
  
• Coumestrol
  
• Miroestrol
  
• Deoxymiroestrol
  

2) Miroestrol (the bioactive component of Pueraria Mirifica) appears to be a quarter as potent as 17β-estradiol in inducing estrogenic like effects. It has been noted that Deoxymiroestrol is actually stronger than Mirosterol (as well as Isomiroestrol) with about 10-fold greater potency in an MCF-7 cell assay relative to Miroestrol. These authors suggested that Deoxymiroestrol should be considered the main bioactive estrogen, since it is plausible that passive oxidation by exposure to the air could have resulted in Miroestrol production from Deoxymirosterol. Relative to the Soy Isoflavones Genistein and Daidzein, the chromene compounds Miroestrol and Deoxymiroestrol are approximately 1,000-10,000 fold more potent on a weight basis (claim stated here, which compares the potencies derived from these two studies[10][12]) and in some studies directly assesing the claim it is found that the soy isoflavones do not contribute towards the majority of estrogenicity.


3)-The chromene compounds are potent and direct estrogen receptor agonists, and Deoxymiroesterol appears to be more potent than 17β-Estradiol itself (17β-Estradiol is the most relevant naturally occuring estrogen compound in the human body)


4) May have similar (in phenotype and potency) anti-androgenic and suppressive effects in the testes as estrogen itself:
-Isolated Miroestrol and Deoxymiroestrol incubated in testes of male mice appear to have similar suppressive effects on enzymes within the steroid synthesis metabolic pathway (17β-HSD1 and CYP19 mRNA, to a lesser degree 3β-HSD and CYP17) while inducing 17β-HSD2 mRNA; the direction of effects and magntiude of effect were similar when comparing the chromenes against estradiol.[61]
(Down regulation of gene related sex hormone synthesis pathway in mouse testes by miroestrol and deoxymiroestrol.) http://www.ncbi.nlm.nih.gov/pubmed/21856387

Pueraria mirifica- (this site is awesome for supplement info!)
http://examine.com/supplements/Pueraria+mirifica/#ref61


5) By modulating androgen receptor coactivators, daidzein may act as a phytoandrogen
http://onlinelibrary.wiley.com/doi/10.10...0/abstract
(Oh yeah, we'll need to talk about this one!).

So lovely11, what do you have on Dexy and miroestriol on its equivalence to E2 over on your Wikiversity?.