[Lotus]

Rhubarb tops the list, crazy!!

referring to toxicity "kind of like rhubarb you have to cook it to eat it " - rocketmelon
A potato is the same way.

What's rhubarb's safety? Also, does it show evidence of inhibiting or promoting action?

Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837008/

Activation of ERβ with rhubarb might be the reason that the extract does not show proliferative effects in uterine tissue, and its antiestrogenic effects could be related to its partial agonistic effects for ERs, which manifest as antagonistic activity when the full agonist, estradiol, is present. In summary, rhubarb is mainly an ERβ activating plant, although its reported active compounds, lindleyin, rhapontigenin, and desoxyrhapontigenin, are not ERβ-selective.

I wouldn't use though......

It's pretty harsh to take.