13-08-2016, 10:13 PM
(13-08-2016, 08:45 PM)ellacraig Wrote:(13-08-2016, 08:41 PM)Lotus Wrote: It's the 2/16 alpha-hydroxyestrone pathway that has roughly a 30% increase in breast cancer. Shifting Estradiol into a safer pathway (end metabolites) of 2OHE1 is safer, (w/Indole-3-Carbinol & DIM etc) increase 2OHE1 urinary excretion (that's good a thing).
Ok so dim is out because im borderline thyroid issues now due to sibo. Does the Indole 3 act the same as Dim?
Alterntively i wonder if the same effects can be acheived by cruciferous veggies, i eat brocilli alot ( i realise that will affect thyroid too) but i have my transdermal iodine which i use regularly,,,,
Sure, cruciferous veggies do the same as Indole 3. Although the supplement way takes out having to eat a ton of veggies, either way it's good protection. DIM, as we found out a couple of years ago is also an anti-androgen. So, I think of DIM as a having dual potential (protecting Breasts and inhibiting DHT).
DIM is a strong antiandrogen that inhibited androgen-dependent tumor cell growth and competitively inhibited androgen receptor translocation and signal transduction. In addition, DIM down-regulated prostate-specific antigen (PSA) expression at the transcriptional level. Results from androgen receptor (AR) competitive binding assays, nuclear translocation studies, and structural modeling computations suggest that DIM disrupts AR function in a manner similar to a chemically dissimilar synthetic antiandrogen, Casodex. Our results identify DIM as a structurally novel, naturally occurring, pure androgen antagonist of potential cancer preventive and therapeutic usefulness for prostate cancer.
http://www.jbc.org/content/278/23/21136.full