[Lotus]

Ok waiting to hear re the transdermal :!

Hi Lotus
I'd like to hear about your new research as well!
Bobbi

Hi Ella and Bobbi, I hope you don't if I put the information here, I'll also attach this post in our BreastNexum site.....w/additional info. 

After reviewing technology used in transdermal patches I noticed the rate of synthesis can fluctuate, but when a combination of certain fatty acids and an organic substance was used the rate of degradation was slowed and its permeability was enhanced. So.....my interpretation for NBE (HRT too) is using Olive Oil and Aloe Vera (in combination) to mirror what I'm about to explain. One other wrinkle before I start is how vital vitamin A (retinol) is to breast growth, think eggs whites and or/tomato juice (low sodium) which tomato juice is high in vitamin A while inhibiting DHT through inhibiting 5 alpha reductase, the enzyme that converts testosterone to DHT (which is  the strongest masculinizing androgen).

Our goal of beautifying breasts will be increasing the permeability of estradiol (or phytoestrogens in the case of NBE) while inhibiting the metabolic degradation. So, exactly how do we go about doing that?......simple, we are going to enhance the permeability and synthesis of estradiol by way (or use) of oleic acid and another organic substance, (more on that later though) in other words, we're extending the time E2 stays active before it shifts to E1 (estrone, which is much weaker than E2 (estradiol).

Take for instance how sublingual E2 spends about 4-6 hrs floating E2 in receptors before it shifts to E1 (less potent estrone), however E1 is certainly still dangerous in relation to metabolites......but this is where glucuronidation is helpful, meaning we excrete the bad metabolite 16 OH-hydroxyestrone (16 OH-E1) out, lessening [not eliminating] risks...see previous post on glucuronidation. Oleic Acid destroys  breast cancer cells:

I have been using this combination olive oil/aloe vera (massaging into the breasts) with noticeable results in a short time (less than 2 weeks), a defined roundness imo, I should note I'm also on hrt though. The aloe vera soaks up the olive oil pretty quick, or pat dry and wipe the excess if your on the go. 

Enhancement of transdermal drug delivery via synergistic action of chemicals — ScienceDirect
http://www.sciencedirect.com/science/art...360900296X


Oleic Acid – The Anti-Breast Cancer Component in Olive Oil 
http://www.journal.au.edu/au_techno/2005...icle02.pdf

These findings demonstrate that oleic acid suppresses Her-2/neu over-expression that in turn interacts synergistically with anti-Her- 2/neu immunotherapy by promoting apoptotic cell death of breast cancer cells with Her-2/neu oncogene amplification. This is a previously unrecognized property of oleic acid. It offers a molecular mechanism that allows individual fatty acid regulation of the malignant behavior of breast cancer cells. This will be helpful in the design of future epidemiological studies and consequently influence dietary counseling (Mendez et al. 2005). 

One or two tablespoons of extra virgin or virgin olive oil per day should provide sufficient oleic acid for adults. However, the ‘time-released’ effects of obtaining these nutrients from nuts and other whole foods is thought to be more beneficial than consuming the entire daily amount via a single oil dose (Rotella 2004). 

Conclusion 
Oleic acid is a monounsaturated fatty acid with a symmetrically placed double bond. Its IUPAC name is cis-9-octadecenoic acid; its lipid shorthand name is 18:1 cis-9 and the CAS registry number is 2027-47-6. Identification of oleic acid as the major component of olive oil that is responsible for a healthy Mediterranean diet, especially for the prevention of breast cancer, precipitated a controversy. The protection of olive oil against breast cancer may be due to oleic acid components rather than to the oil itself.