07-02-2017, 06:00 AM
(06-02-2017, 11:29 PM)EllaC Wrote: Hey Lotus. One thing.. You talk about "estradiol degradation" in this method. For ME this isnt good is it now we know i might not metabolise estrogen right? Should i NOT try this methid?
Aloe lowers plasma glucose....though some people shouldn't take regular amounts (1-2 tablespoons) of Aloe for various reasons as discussed in the study. Meta analysis showed 1 report of increased hypothyroidism in a woman. Olive oil can alter estrogen metabolism (if needed) and improve thyroid function...soy lowers thyroid function....that's going in the wrong direction tbh.
Extra virgin olive oil potentiates the effects of aromatase inhibitors via glutathione depletion in estrogen receptor-positive human breast cancer (MCF-7) cells.
Ismail AM1, In LL, Tasyriq M, Syamsir DR, Awang K, Mustafa AH, Idris OF, Fadl-Elmula I, Hasima N.
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Abstract
There have been numerous evidences supporting the relationship between olive oil and cancer, with most of the attention being directed toward its fat and phenolic content. The aims of this study were to investigate whether EVOO and OA could enhance the effects of aromatase inhibitors (letrozole and anastrozole) in ER-positive MCF-7 cells, as well as to investigate its influence on cytochrome c release and GSH levels. It was observed that upon combination treatment, anti-proliferation effects and apoptosis induction were augmented. Apoptosis was triggered via the intrinsic pathway in accordance with cytochrome c release into the cytosol based on IF-IC and ELISA observations. Intracellular GSH levels were also reduced upon EVOO/OA treatment in combination with aromatase inhibitors, and were found to be inversely correlated to cytosolic cytochrome c levels. Additionally, the estrogenic suppressive effects of letrozole and anastrozole were amplified when used in combination with EVOO/OA. Therefore, the employment of aromatase inhibitors in combination with EVOO/OA could orchestrate a reduction in intracellular estrone biosynthesis which feeds ER-positive cells, while simultaneously depleting GSH levels and increasing ROS generation, thus releasing cytochrome c and subsequent induction of apoptosis in MCF-7 cells.
Copyright © 2013 Elsevier Ltd. All rights reserved.