(24-02-2017, 06:14 AM)Atom Wrote:
(07-02-2017, 06:00 AM)Lotus Wrote:
(06-02-2017, 11:29 PM)EllaC Wrote: Hey Lotus. One thing.. You talk about "estradiol degradation" in this method. For ME this isnt good is it now we know i might not metabolise estrogen right? Should i NOT try this methid?
Aloe lowers plasma glucose....though some people shouldn't take regular amounts (1-2 tablespoons) of Aloe for various reasons as discussed in the study. Meta analysis showed 1 report of increased hypothyroidism in a woman. Olive oil can alter estrogen metabolism (if needed) and improve thyroid function...soy lowers thyroid function....that's going in the wrong direction tbh.
Extra virgin olive oil potentiates the effects of aromatase inhibitors via glutathione depletion in estrogen receptor-positive human breast cancer (MCF-7) cells.
Ismail AM1, In LL, Tasyriq M, Syamsir DR, Awang K, Mustafa AH, Idris OF, Fadl-Elmula I, Hasima N.
There have been numerous evidences supporting the relationship between olive oil and cancer, with most of the attention being directed toward its fat and phenolic content. The aims of this study were to investigate whether EVOO and OA could enhance the effects of aromatase inhibitors (letrozole and anastrozole) in ER-positive MCF-7 cells, as well as to investigate its influence on cytochrome c release and GSH levels. It was observed that upon combination treatment, anti-proliferation effects and apoptosis induction were augmented. Apoptosis was triggered via the intrinsic pathway in accordance with cytochrome c release into the cytosol based on IF-IC and ELISA observations. Intracellular GSH levels were also reduced upon EVOO/OA treatment in combination with aromatase inhibitors, and were found to be inversely correlated to cytosolic cytochrome c levels. Additionally, the estrogenic suppressive effects of letrozole and anastrozole were amplified when used in combination with EVOO/OA. Therefore, the employment of aromatase inhibitors in combination with EVOO/OA could orchestrate a reduction in intracellular estrone biosynthesis which feeds ER-positive cells, while simultaneously depleting GSH levels and increasing ROS generation, thus releasing cytochrome c and subsequent induction of apoptosis in MCF-7 cells.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Can you say how much and how often you were applying the olive oil? 60% weight increase in a few weeks is amazing. Did you rule out other effects that may have caused such a huge gain in such a short time, e.g., water weight gain? Or do you think the gain is in mammary tissue or fat or both? Is olive oil essential or is it just any oil with similar levels of oleic acid? From what I remember reading Almond oil goes deeper than olive oil at skin penetration with similar oleic acid percentage, and apricot oil may be even better than almond at penetration with high oleic acid as well. I don't have that info handy but I remember reading about it a few years ago when looking into moisturizing oils.
Thanks for the (excellent) questions Atom,
I added olive oil (about 1 tsp. sublingually x2 daily) about 6-8 weeks ago with sublingual E2 (hrt), it's an adjustment at first (minor throat irritation). I also went more for a mediterranean diet and actually lost weight (about 8 pounds) in that time period....so water weight didn't factor (currently on spiro/magnesium). I did another weight test and haven't lost any of the increased breast weight, in fact there was a 2-3% increase in breast weight since the last test (2 weeks ago?). The massage portion is 3x minimum a week in my case, (Jojoba oil I think could work too).
When you analyze fat intake vs. fat expenditure therein lays the opportunity for breast growth in my opinion, of course supplementing with certain vitiamins & hormones are also critical for success too. I'll post the subsequent science for those interested.
I will point out that the parathyroid plays a huge factor in bud development in embryonic delevolpment, but new science says it still can be revelant past puberty (protection of lost breast volume).........think vitamin D3. (study by Colorado state university).
I choose Aloe Vera because of its lower molecular weight (ability to diffuse through the skin layers past the dermis) and its polymers. This dalton rule is helpful determining molecular weight for transdermal applications, the smaller the molecule the easier to diffuse......Almond oil looks interesting (thanks again atom). Now I also found out that the skin should be irritated prior for skin application for a higher success rate.....lol I know what your thinking
that Thailand breast slap...haha (no comment). Personally?, I'd say using a cayenne pepper extract (sauce?) would provide plenty of irritation. Btw, vitamin C produces collagen.
Btw, for those whose domes steam up during pumping I've determined it's a build up humidity, thus water (ambient air---inside the dome) being pulled into the breast. I also believe it's in part relevant to thermogenesis (or heat transfer) aiding synthesis of mitochondria......(I could be wrong though).
The 500 Dalton rule for the skin penetration of chemical compounds and drugs
* Jan D. Bos, Marcus M. H. M. Meinardi
* First published: June 2000Full publication history
* DOI: 10.1034/j.1600-0625.2000.009003165.xView/save citation
* Cited by: 370 articles
Jan D. Bos, Department of Dermatology A0-235, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands
Tel.: +31 20 566 2587. Fax: +31 20 696 0076
Abstract: Human skin has unique properties of which functioning as a physicochemical barrier is one of the most apparent. The human integument is able to resist the penetration of many molecules. However, especially smaller molecules can surpass transcutaneously. They are able to go by the corneal layer, which is thought to form the main deterrent. We argue that the molecular weight (MW) of a compound must be under 500 Dalton to allow skin absorption. Larger molecules cannot pass the corneal layer.
Arguments for this “500 Dalton rule” are; 1) virtually all common contact allergens are under 500 Dalton, larger molecules are not known as contact sensitizers. They cannot penetrate and thus cannot act as allergens in man; 2) the most commonly used pharmacological agents applied in topical dermatotherapy are all under 500 Dalton; 3) all known topical drugs used in transdermal drug-delivery systems are under 500 Dalton. In addition, clinical experience with topical agents such as cyclosporine, tacrolimus and ascomycins gives further arguments for the reality of the 500 Dalton rule. For pharmaceutical development purposes, it seems logical to restrict the development of new innovative compounds to a MW of under 500 Dalton, when topical dermatological therapy or percutaneous systemic therapy or vaccination is the objective.
Molecular Weights: (g/mol)
Aloe Vera- 270.24
Stearic - 298.52
Oleic - 282.46
Linoleic - 298.48
Almond oil - 106.12
Estradiol - 272.4
Soybean oil -292.2