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FAQ-Supplements for breast growth
(24-02-2017, 06:14 AM)Atom Wrote:
(07-02-2017, 06:00 AM)Lotus Wrote:
(06-02-2017, 11:29 PM)EllaC Wrote: Hey Lotus. One thing.. You talk about "estradiol degradation" in this method. For ME this isnt good is it now we know i might not metabolise estrogen right? Should i NOT try this methid?


Aloe lowers plasma glucose....though some people shouldn't take regular amounts (1-2 tablespoons) of Aloe for various reasons as discussed in the study. Meta analysis showed 1 report of increased hypothyroidism in a woman. Olive oil can alter estrogen metabolism (if needed) and improve thyroid function...soy lowers thyroid function....that's going in the wrong direction tbh. 


Extra virgin olive oil potentiates the effects of aromatase inhibitors via glutathione depletion in estrogen receptor-positive human breast cancer (MCF-7) cells.
Ismail AM1In LLTasyriq MSyamsir DRAwang KMustafa AHIdris OFFadl-Elmula IHasima N.
Author information

Abstract
There have been numerous evidences supporting the relationship between olive oil and cancer, with most of the attention being directed toward its fat and phenolic content. The aims of this study were to investigate whether EVOO and OA could enhance the effects of aromatase inhibitors (letrozole and anastrozole) in ER-positive MCF-7 cells, as well as to investigate its influence on cytochrome c release and GSH levels. It was observed that upon combination treatment, anti-proliferation effects and apoptosis induction were augmented. Apoptosis was triggered via the intrinsic pathway in accordance with cytochrome c release into the cytosol based on IF-IC and ELISA observations. Intracellular GSH levels were also reduced upon EVOO/OA treatment in combination with aromatase inhibitors, and were found to be inversely correlated to cytosolic cytochrome c levels. Additionally, the estrogenic suppressive effects of letrozole and anastrozole were amplified when used in combination with EVOO/OA. Therefore, the employment of aromatase inhibitors in combination with EVOO/OA could orchestrate a reduction in intracellular estrone biosynthesis which feeds ER-positive cells, while simultaneously depleting GSH levels and increasing ROS generation, thus releasing cytochrome c and subsequent induction of apoptosis in MCF-7 cells. 
Copyright © 2013 Elsevier Ltd. All rights reserved.


Can you say how much and how often you were applying the olive oil? 60% weight increase in a few weeks is amazing.  Did you rule out other effects that may have caused such a huge gain in such a short time, e.g., water weight gain? Or do you think the gain is in mammary tissue or fat or both? Is olive oil essential or is it just any oil with similar levels of oleic acid? From what I remember reading Almond oil goes deeper than olive oil at skin penetration with similar oleic acid percentage, and apricot oil may be even better than almond at penetration with high oleic acid as well. I don't have that info handy but I remember reading about it a few years ago when looking into moisturizing oils.


Thanks for the (excellent) questions Atom, 

I added olive oil (about 1 tsp. sublingually x2 daily) about 6-8 weeks ago with sublingual E2 (hrt), it's an adjustment at first (minor throat irritation). I also went more for a mediterranean diet and actually lost weight (about 8 pounds) in that time period....so water weight didn't factor (currently on spiro/magnesium). I did another weight test and haven't lost any of the increased breast weight, in fact  there was a 2-3% increase in breast weight since the last test (2 weeks ago?). The massage portion is 3x minimum a week in my case, (Jojoba oil I think could work too). 

When you analyze fat intake vs. fat expenditure therein lays the opportunity for breast growth in my opinion, of course supplementing with certain vitiamins & hormones are also critical for success too. I'll post the subsequent science for those interested. 

I will point out that the parathyroid plays a huge factor in bud development in embryonic delevolpment, but new science says it still can be revelant past puberty (protection of lost breast volume).........think vitamin D3. (study by Colorado state university). 

I choose Aloe Vera because of its lower molecular weight (ability to diffuse through the skin layers past the dermis) and its polymers. This dalton rule is helpful determining molecular weight for transdermal applications, the smaller the molecule the easier to diffuse......Almond oil looks interesting (thanks again atom). Now I also found out that the skin should be irritated prior for skin application for a higher success rate.....lol I know what your thinking  Rolleyes that Thailand breast slap...haha (no comment). Personally?, I'd say using a cayenne pepper extract (sauce?) would provide plenty of irritation. Btw, vitamin C produces collagen.

Btw, for those whose domes steam up during pumping I've determined it's a build up humidity, thus water (ambient air---inside the dome) being pulled into the breast. I also believe it's in part relevant to thermogenesis (or heat transfer) aiding synthesis of mitochondria......(I could be wrong though). 


The 500 Dalton rule for the skin penetration of chemical compounds and drugs
Authors
* Jan D. Bos, Marcus M. H. M. Meinardi
* First published: June 2000Full publication history
* DOI: 10.1034/j.1600-0625.2000.009003165.xView/save citation
* Cited by: 370 articles

Jan D. Bos, Department of Dermatology A0-235, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands
Tel.: +31 20 566 2587. Fax: +31 20 696 0076
e-mail:  j.d.bos@amc.uva.nl
Abstract
Abstract: Human skin has unique properties of which functioning as a physicochemical barrier is one of the most apparent. The human integument is able to resist the penetration of many molecules. However, especially smaller molecules can surpass transcutaneously. They are able to go by the corneal layer, which is thought to form the main deterrent. We argue that the molecular weight (MW) of a compound must be under 500 Dalton to allow skin absorption. Larger molecules cannot pass the corneal layer. Arguments for this “500 Dalton rule” are; 1) virtually all common contact allergens are under 500 Dalton, larger molecules are not known as contact sensitizers. They cannot penetrate and thus cannot act as allergens in man; 2) the most commonly used pharmacological agents applied in topical dermatotherapy are all under 500 Dalton; 3) all known topical drugs used in transdermal drug-delivery systems are under 500 Dalton. In addition, clinical experience with topical agents such as cyclosporine, tacrolimus and ascomycins gives further arguments for the reality of the 500 Dalton rule. For pharmaceutical development purposes, it seems logical to restrict the development of new innovative compounds to a MW of under 500 Dalton, when topical dermatological therapy or percutaneous systemic therapy or vaccination is the objective.
http://onlinelibrary.wiley.com/doi/10.10...x/abstract



Molecular Weights: (g/mol)

Aloe Vera- 270.24

Palmitic- 270.46

Stearic - 298.52

Oleic -  282.46 

Linoleic - 298.48

Almond oil - 106.12

Estradiol - 272.4

Soybean oil -292.2

http://biodiesel.org/docs/ffs-performace...f?sfvrsn=4


♦NBE Formula→Free Testosterone→5 alpha inhibitors→Aromatase→E1/E2....DNA→RNA→Protein ♦
♦Regulation of Estrogen & Progesterone-Hypothalamus→GnRH→Pituitary→FSH→Follicle→Estrogens ♦
♦ego cogito, ergo sum TG.
 Reply
Green Tea-(updated version 2017):

promotes aromatase, increases GABA, promotes estrogen and estrogen gene target receptor (pS2) and PR-progesterone, modifies signaling transduction pathways, antioxidant (relieves oxidative stress & reduces lipid oxidation), possess potent iron-chelating radical-scavenging and anti-inflammatory activities (polyphenols EGCG Epigallocatechin 3-gallate-inhibits DHT and are powerful free radical destroyers), protects against neurological diseases. Green tea catechins ameliorate adipose insulin resistance, anti-androgen (inhibits DHT), stimulates beta-receptors at fat cells to increase release of lipids into the bloodstream, Green Tea displaces estradiol in SHBG, making a higher bioavailability of E2 (in the blood) benefiting delivery to target tissues. I believe green tea acts like a generic herbal version of Spirolactone.


 If you'd like more information about " steroidal and natural lactones " see here:
http://www.breastnexum.com/showthread.ph...#pid194280

(30-01-2015, 09:08 PM)Lotus Wrote: http://www.sciencedirect.com/science/art...1714000056
New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

Highlights

Many biological actions of EGCG are mediated by specific mechanisms other than its well-known anti-oxidant properties.

EGCG is a pro-oxidant per se in some biological contexts.

EGCG directly interacts with cell surface membrane proteins and specific known receptors.

Treatment of cells with EGCG regulates specific intracellular signaling pathways and transcription.

Specific biological actions of EGCG are regulated in a concentration-dependent manner.
Abstract
Green tea is rich in polyphenol flavonoids including catechins. Epigallocatechin 3-gallate (EGCG) is the most abundant and potent green tea catechin. EGCG has been extensively studied for its beneficial health effects as a nutriceutical agent. Based upon its chemical structure, EGCG is often classified as an antioxidant. However, treatment of cells with EGCG results in production of hydrogen peroxide and hydroxyl radicals in the presence of Fe (III). Thus, EGCG functions as a pro-oxidant in some cellular contexts. Recent investigations have revealed many other direct actions of EGCG that are independent from anti-oxidative mechanisms. In this review, we discuss these novel molecular mechanisms of action for EGCG. In particular, EGCG directly interacts with proteins and phospholipids in the plasma membrane and regulates signal transduction pathways, transcription factors, DNA methylation, mitochondrial function, and autophagy to exert many of its beneficial biological actions.



(30-12-2016, 11:22 PM)Lotus Wrote:
(29-12-2016, 10:08 PM)Atom Wrote: I guess you are saying that it is more important to squash the more potent DHT than whatever level of inhibition of aromatase is caused by Silybin? Also about the other thing you mentioned: how does its inactivation of P450 3A4 and inhibiting of Glucuronidation affect NBE? Thanx. Wink


Exactly, squash DHT by multiple means (pathways) and we'd see better gains. 

Re: Glucuronidation- think of Glucuronidation as a process to eliminate toxins (too detoxify) from tissues, (via excretion). see this attached study below as an example of using glucuronidation. As we know, GTE inhibits DHT.......it's all relative lol. 

Free Radic Res. 2004 Sep;38(9):1025-31.
Glucuronidation of the green tea catechins, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate, by rat hepatic and intestinal microsomes.
Crespy V1, Nancoz N, Oliveira M, Hau J, Courtet-Compondu MC, Williamson G.
Author information


Abstract
The flavonoids (-)-epigallocatechin-3-gallate (EGCg) and (-)-epicatechin-3-gallate (ECg) are major components of green tea and show numerous biological effects. We investigated the glucuronidation of these compounds and of quercetin by microsomes. Quercetin was almost fully glucuronidated by liver microsomes after 3 h, whereas ECg and ECGg were conjugated to a lesser extent (12.2 +/- 0.2 and 7.5 +/- 0.2%, respectively). The intestinal microsomes also glucuronidated quercetin much more efficiently than ECg and EGCg. Although the rates were lower than quercetin, intestinal microsomes exhibited higher activity on the galloyl group of ECg and EGCg compared to the flavonoid ring, whereas hepatic glucuronidation was higher on the flavonoid ring of EGCg and ECg compared to the galloyl groups. The low glucuronidation rates could partially explain why these flavanols are present in plasma as unconjugated forms.


(30-01-2015, 07:27 PM)Lotus Wrote: Polyphenols (specifically Green Tea) promotes aromatase, anti-oxidation, estrogen, modifies signaling transduction pathways, relieves oxidative stress (reduces lipid oxidation), possess potent iron-chelating radical-scavenging and anti-inflammatory activities (polyphenols are powerful free radical destroyers), protects against neurological diseases. Green tea catechins ameliorate adipose insulin resistance. 


(11-06-2016, 10:46 PM)Lotus Wrote: Green Tea - stimulates beta-receptors at fat cells to increase release of lipids into the bloodstream. why is this important?, 95-98% fatty acids are bound in the blood stream (just like hormones are), we needed something that displaces hormones and fatty acids, looks like green tea is up for the task. 


(10-05-2016, 08:14 PM)Lotus Wrote: green tea raises growth hormone (theanine in tea raises GABA), even at resting.
Determination of theanine, GABA, and other amino acids in green, oolong, black, and Pu-erh teas with dabsylation and high-performance liquid chromatography.
Syu KY, et al. J Agric Food Chem. 2008.
Show full citation
Abstract
Dabsyl chloride (dimethylaminoazobenzene sulfonyl chloride), a useful chromophoric labeling reagent for amino acids and amines, was developed in this laboratory in 1975. Although several methods have been developed to determine various types of amino acids, a quick and easy method of determining theanine, GABA, and other amino acids has not been developed in one HPLC system. In this paper are analyzed the free amino acid contents of theanine and GABA in different teas (green tea, black tea, oolong tea, Pu-erh tea, and GABA tea) with a dabsylation and reverse phase high-performance liquid chromatography (HPLC) system coupled with a detector at 425 nm absorbance. Two reverse phase columns, Hypersil GOLD and Zorbax ODS, were used and gave different resolutions of dabsyl amino acids in the gradient elution program. The data suggest that the tea source or the steps of tea-making may contribute to the theanine contents variations. High theanine contents of high-mountain tea were observed in both green tea and oolong tea. Furthermore, the raw (natural fermented) Pu-erh tea contained more theanine than ripe (wet fermented) Pu-erh tea, and the GABA contents in normal teas were generally lower than that in GABA tea.
PMID 18652476 [PubMed - indexed for MEDLINE]


(28-04-2016, 09:34 PM)Lotus Wrote: Green Tea displaces estradiol in SHBG, making a higher bioavailability of E2 (in the blood) benefiting delivery to target tissues. As said before, green tea raises SHBG and free's E2 (blood serum), I really believe it acts like a generic herbal version of Spirolactone.

Green Tea Epigallocatechin-Green tea (camellia)-Reduce's the conversion of free testosterone into DHT and also raises SHBG (sex-hormone-binding-globulin). Also is for breast cancer prevention, reduces visceral fat.


(06-02-2016, 01:14 AM)Lotus Wrote: In this study (animal) aromatase expression increased in the AT (318.5 +/- 60.6% of control in scAT, P n< 0.05, and 285.5 +/- 82.9% of control in vAT,

That's 60.6% in subcutaneous fat and 82.9% in visceral fat. 

(24-01-2015, 10:47 PM)Lotus Wrote: Chronic green tea consumption decreases body mass, induces aromatase expression, and changes proliferation and apoptosis in adult male rat adipose tissue.

Abstract
Green tea (GT) and its components have been shown to possess antiobesity properties and the corresponding mechanisms of action are being investigated, given the epidemic proportions of obesity incidence. In the current work, we used 12-mo-old male Wistar rats to test the effect of 6 mo of treatment with GT as the sole drinking beverage (52.8 +/- 6.4 mL/d) on adipose tissue (AT). AT aromatase expression was determined by Western blotting, plasma concentrations of 17beta-estradiol and testosterone were determined by RIA, and adipocyte size determined by measuring diameter in tissue sections. Proliferation and apoptosis were also assessed by Ki67 immunostaining and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling, respectively. Evaluations were made in subcutaneous (sc) AT and visceral (v) AT. Body weight increased over time in both groups (P < 0.001), but the increase was more pronounced in controls (P < 0.001) and food and fluid intake did not influence that effect. At the end of the experiment, aromatase expression increased in the AT (318.5 +/- 60.6% of control in scAT, P < 0.05, and 285.5 +/- 82.9% of control in vAT, P < 0.01). AT of GT-treated rats had a higher percentage of proliferating cells (204.1 +/- 19.5% of control in scAT, P < 0.01, and 246.6 +/- 50.2% of control in vAT, P < 0.01) and smaller adipocytes (78.3 +/- 1.7% of control in scAT, P < 0.001, and 87.9 +/- 3.2% of control in vAT, P < 0.05). GT also increased the number of apoptotic cells in vAT (320.4 +/- 21.9% of control; P < 0.001). These results suggest new mechanisms for GT on body weight and highlight its potential benefit to prevent or treat obesity and the metabolic syndrome.

http://www.ncbi.nlm.nih.gov/pubmed/18936213#


(13-02-2016, 09:01 PM)Lotus Wrote: The polyphenols (EGCG) in green tea absolutely inhibit DHT, (and in pharma strength I might add). Polyphenols inhibit 5 alpha reductase type 1. Dutaseride inhibits type 1 & 2 @ about 93%, effective but carries risk. Red clover, genistien (others too) inhibit type 2 (5 ar). 

Green tea protects the prostate and also lowers PSA levels too, which is why I'd still take it.


(18-08-2015, 07:04 PM)Lotus Wrote: Btw, 

Green tea can increases a steady state expression level of pS2 and PR mRNA, which mRNA conveys genetic information from DNA to the ribosome (in other words-synthesis).

pS2-is an estrogen target gene 
PR-is progesterone receptor

Epigallocatechin gallate induces the steady state mRNA levels of pS2 and PR genes in MCF-7 breast cancer cells.
C Mohan C Manjegowda, Gauri Deb, Anil M Limaye


Abstract
Investigations using in vitro and in vivo models of breast carcinogenesis have demonstrated anti-neoplastic activity of the green tea polyphenol, epigallocatechin gallate (EGCG). Although a number of molecular targets of EGCG have been identified, its impact on the expression of estrogen target genes is not completely understood. Here, we examined the mRNA expression levels of two estrogen target genes, namely Trefoil Factor 1 (pS2) and Progesterone Receptor (PR) in MCF-7 cells treated with EGCG. We observed that treatment with 40 microM EGCG, which caused only 20% decrease in cell viability, resulted in increased steady state expression levels of pS2 and PR mRNA. This suggests that EGCG may exert its biological activities, at least in part, by influencing the expression of estrogen target genes


(31-01-2015, 10:18 PM)Lotus Wrote: Further benefits of Green Tea

EGCG plays an important role in lipid metabolism in whole body physiology as well as at the cellular level.

EGCG directly interacts with plasma membrane proteins and phospholipids which stimulates intracellular signaling pathways. In addition, EGCG is transported to intracellular compartments, cytosol, mitochondria, lysosome, and nucleus where it mediates additional biological actions.


(30-01-2015, 08:20 PM)Lotus Wrote: What Are the Benefits of Green Tea Essential Oil?

Properties
Green tea essential oil has many useful properties that make it beneficial. It is an astringent; this means it has the property to constrict and shrink body tissue. It is an antioxidant; this means it neutralizes free radicals in the body. Free radicals occur naturally in the body, but are also produced by exposure to ultraviolet rays, radiation, cigarette smoke and air pollution. They are responsible for cell and DNA damage. Tea seed oil has anti-inflammatory properties. It also has anti-aging properties as it inhibits the breakdown of collagen that is responsible for keeping the skin firm and elastic.

Therapeutic Benefits
Green tea essential oil, and green tea leaves are widely used because of their beneficial properties. Green tea oil is used in the cosmetics industry to manufacture creams, soaps, shampoos, hair conditioners, lotions, perfumes and massage oils, because of its anti-aging, anti-inflammatory and astringent properties.

It is used as a therapeutic oil in aromatherapy. Five drops of tea seed oil mixed in 10 ml of carrier oil can be added to a warm bath to relax the muscles. Six drops can be added to water and used in a tea light oil burner or electric oil diffuser to create a soothing environment. Green tea essential oil is also used to make candles and potpourri.

Read more : http://www.ehow.com/about_6514882_benefi...-oil_.html



♦NBE Formula→Free Testosterone→5 alpha inhibitors→Aromatase→E1/E2....DNA→RNA→Protein ♦
♦Regulation of Estrogen & Progesterone-Hypothalamus→GnRH→Pituitary→FSH→Follicle→Estrogens ♦
♦ego cogito, ergo sum TG.
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