Hormone pathways:
![[Image: attachment.php?aid=8379]](http://www.breastnexus.com/attachment.php?aid=8379)
Based on Estriol:Safety and Efficacy, and information from Wikipedia and NLM.
16-alpha-Hydroxylase (16α-OHase) is a liver enzyme, that is in many pathways to estriol.
Most estradiol is bound to SHBG. While estriol is 10s of times less potent than estradiol, estriol is 10s of times more bio-available. Estriol is also safer than estradiol or estrone, but still, estriol must be seen with caution. Normally, very little estradiol or estrone converts into estradiol via the liver.
There are other metabolites of estrogens too. Toxins (including synthetics) can cause estriol to metabolize into carcinogenic compounds. Eating healthy foods including plant fiber can help estriol metabolize into safe compounds.
(All endogenous hormones necessary for normal function)
Progesterone and Prolactin Feedback Loop:
![[Image: attachment.php?aid=8382]](http://www.breastnexus.com/attachment.php?aid=8382)
Progesterone, Prolactin and Estradiol interaction:
![[Image: attachment.php?aid=8385]](http://www.breastnexus.com/attachment.php?aid=8385)
Based on Estriol:Safety and Efficacy, and information from Wikipedia and NLM.
16-alpha-Hydroxylase (16α-OHase) is a liver enzyme, that is in many pathways to estriol.
Most estradiol is bound to SHBG. While estriol is 10s of times less potent than estradiol, estriol is 10s of times more bio-available. Estriol is also safer than estradiol or estrone, but still, estriol must be seen with caution. Normally, very little estradiol or estrone converts into estradiol via the liver.
There are other metabolites of estrogens too. Toxins (including synthetics) can cause estriol to metabolize into carcinogenic compounds. Eating healthy foods including plant fiber can help estriol metabolize into safe compounds.
(All endogenous hormones necessary for normal function)
Progesterone and Prolactin Feedback Loop:
Progesterone, Prolactin and Estradiol interaction: