[Lotus]

Open Research Topics

"What's also interesting is how upon excertion steroids are water soluble"-->
mmh... why do you want to know that? for transport?

Yes exactly, (for transport), ion channels are the access of cell diffusion correct?, assuming carrier proteins are the vehicles to mitochondria, what keeps the channels open long enough expression?, I see its from 1/100 hundredth to 1/1000 thousands of seconds, could this explain partial binding?.

I think that there is no necessity of a ion channel for the access of steroids in the cell. They should simply cross the membranes by diffusion:

"After secretion by the endocrine glands, the hormones are transported to the target tissues via the blood, where their major fraction is bound to the serum proteins β-globulin and albumin. According to the genomic mechanism, the lipophilic character of the hormones enables them to dissociate spontaneously from the carriers and enter the target cell by transbilayer passive diffusion. Inside the cell, the hormones bind to intracellular receptors that shuttle between the nucleus and the cytoplasm in an inactive state (Lundberg, 1979). Binding to the hormones induces conformational changes and reorganization to active hormone-receptor complexes (Guiochon-Mantel et al., 1996). Subsequently, the complexes migrate to the nucleus, where they bind to hormone-responsive elements on the DNA and regulate synthesis of new proteins that are required for the hormone's action (Chen and Farese, 1999; Beato and Klug, 2000)."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1304487/

Ok, I understand the "conformational changes and reorganization to active hormone-receptor complexes" now, it took a few months tbh, but I got it now.

I think that DHT is not converted to the "estrogen-like metabolite" in the breast, at least not in the same amount as it is in the prostate.

a hypothetical about DHT, (but first), for the longest time I thought DHT had no usable purpose in terms of breast growth. Now, we discover it has a back door useable metabolite in the prostrate and Sertoli cells. So....then, is it yet to be discovered that DHT in breast tissue "can" in fact....have the usable ER-beta metabolite??.....that is my hypothetical, I see you think perhaps the same is true.

We've just opened a whole can of worms.......imo it's the gummi type (yum yum).

yes it could be... if you can convert the majority of DHT, in breast tissue, it could be a way for NBE. But i think that this method is quite difficoult to obtain... you should enhance the enzyme that give you 3b-diol, but honestly I dont know how this could be possible.

Honestly that's encouraging news, the possibity of DHT actually being anything of therapeutic value in breast tissue (besides research purposes) is well....uhm....cool.