[Lotus]

Besides very high IGF and HGF in macromastia cases, moderately higher IGF is found in women with large boobs too.  I also read about large chested women exercising their back, using good posture and so on to avoid any back pain.  Plus 32H's are only 2 pounds a boob, so even they aren't a major concern.  5-6 lbs each is 32O (or 36M, etc.):
http://kdwb.iheart.com/onair/the-dave-ry...-12418095/

A radio station? that's what we're using for scientific information?, um ok, whatever. Even using their information (which doesn't measure extended cup size DD/DDD - GG/ HHH etc.......is as follows). If you had large breasts you'd might think twice about saying it's not a major concern, all breasts aren't (and weigh) the same. 


44
46A 44B 42C 40D 38E 36F 34G 32H 30I 28J
15.7 cm (6 in 1/6)
1,000 cc (2.1 US pt)
1.8 kg (4.0 lb)

46
48A 46B 44C 42D 40E 38F 36G 34H 32I 30J 28K
16.5 cm (6 in 1/2)
1,180 cc (2.5 US pt)
2.1 kg (4.6 lb)

48
50A 48B 46C 44D 42E 40F 38G 36H 34I 32J 30K 28L
17.4 cm (6 in 5/6)
1,370 cc (2.9 US pt)
2.5 kg (5.5 lb)


J Plast Reconstr Aesthet Surg. 2011 Feb;64(2):160-3. doi: 10.1016/j.bjps.2010.04.043. Epub 2010 Jun 8.

Redefining gigantomastia.
Dafydd H1, Roehl KR, Phillips LG, Dancey A, Peart F, Shokrollahi K.
Author information


Abstract
Gigantomastia is a rare but disabling condition characterised by excessive breast growth. Most definitions of gigantomastia refer to a particular weight of excess breast tissue. We speculate that in gigantomastia the weight of the breasts contributes significantly to the BMI, which has implications for healthcare rationing. This study aims to establish the contribution breast tissue makes to BMI in gigantomastia. In so doing, we propose a new definition of gigantomastia. Retrospective data was collected from the case notes of 68 females who underwent breast reduction or therapeutic mastectomy for gigantomastia. For the purposes of patient inclusion, gigantomastia is arbitrarily defined as excessive breast growth of over 1.5kg per breast. The difference between pre- and post-operative BMI is statistically significant (P<0.001). Mean pre-operative BMI is 38.7 with a mean specimen weight of 4506g. Mean contribution of specimen to body weight is 4.29%. There is no correlation between pre-operative body weight and the percentage contribution the breast resection specimen makes to body weight. Based on our data, we define gigantomastia as excess breast tissue that contributes 3% or more to the patient's total body weight, approximately one standard deviation below the mean. We suggest that the estimated excess breast tissue weight is taken into account when calculating pre-operative BMI in the gigantomastia population. The challenge of estimating excess breast weight pre-operatively may be met by 3D photography coupled with computer-assisted volumetry.
https://www.ncbi.nlm.nih.gov/pubmed/20965141

I'm confused what you're getting at regarding HGF.  Is it a risk for cancer, or a way to avoid that risk?  Regardless IGF seems to be the main factor here (plus estrogen, progesterone and so on of course).  Even though it's not as great as IGF+HGF.  Plus with certain hormones the body can make HGF.

Yes, reduces cancer risk and offers a possible alternative theory for achieving results, however, it's more depth an explanation than I care to share at this point, sorry. Good luck w/the thread.