12-07-2012, 12:33 PM
Hi Karen,
You can start at 3,000 mg hops, but take a couple of days to ramp up.
A phyto-estrogen with a stronger binding affinity has to wait until a weaker one leaves. But chemical equilibrium is dynamic: every second, a lot of estrogens leave the receptors, to be replaced by others with equal, higher, or even lower binding affinity. Look at the publication you linked: the IC50 is the concentration of the tested estrogen that causes 50 % inhibition of the competitive binding of estradiol. The lower the concentration, the lower the dose you can take for the same effect, so the stronger the tested estrogen.
A daily dose is a good average for most of the steroids. You ramp up over two or three days until you reach the right concentration. Exceptions are estriol, estrone, and goat's rue: they metabolize fast. Some changes are much slower because they involve more than metabolism: like stalling, which requires the active intervention of a gland. For synthetics, like testim, the pharmacokinetics is in the documentation.
You can start at 3,000 mg hops, but take a couple of days to ramp up.
A phyto-estrogen with a stronger binding affinity has to wait until a weaker one leaves. But chemical equilibrium is dynamic: every second, a lot of estrogens leave the receptors, to be replaced by others with equal, higher, or even lower binding affinity. Look at the publication you linked: the IC50 is the concentration of the tested estrogen that causes 50 % inhibition of the competitive binding of estradiol. The lower the concentration, the lower the dose you can take for the same effect, so the stronger the tested estrogen.
A daily dose is a good average for most of the steroids. You ramp up over two or three days until you reach the right concentration. Exceptions are estriol, estrone, and goat's rue: they metabolize fast. Some changes are much slower because they involve more than metabolism: like stalling, which requires the active intervention of a gland. For synthetics, like testim, the pharmacokinetics is in the documentation.