09-06-2014, 20:16
Why increasing the dosage doesn't always work
Negative feedback occurs when the result of a process influences the operation of the process itself in such a way as to reduce changes. Feedback can produce stability and reduce the effect of fluctuations. Negative feedback loops in which just the right amount of correction is applied in the most timely manner can be very stable, accurate, and responsive.
Negative feedback loops have been compared to a thermostatically controlled temperature in a house, where the internal temperature is monitored by a temperature-sensitive gauge in the thermostat. If it is cold outside, eventually the internal temperature of the house drops, as cold air seeps in through the walls. When the temperature drops below the point at which the thermostat is set, the thermostat turns on the furnace. As the temperature within the house rises, the thermostat again senses this change and turns off the furnace when the internal temperature reaches the pre-set point.
Negative feedback loops require a receptor, a control center, and an effector. A receptor is the structure that monitors internal conditions. For instance, the human body has receptors in the blood vessels that monitor the pH of the blood. The blood vessels contain receptors that measure the resistance of blood flow against the vessel walls, thus monitoring blood pressure. Receptors sense changes in function and initiate the body's homeostatic response.
Read more: Homeostasis - Negative feedback - Body, Blood, Internal, and Conditions - JRank Articles http://science.jrank.org/pages/3365/Home...z34AWy8WWP
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Cycling is important when taking supplements, failure to do so will result with tolerance, and the supplements will stop working.
Once your body makes the adjustments to get back to homeostasis is the time to cycle, (ie. in a 7 day plan, try 5 days on and 2 days off).
Tolerance occurs when the person no longer responds to the drug in the way that person initially responded. Stated another way, it takes a higher dose of the drug to achieve the same level of response achieved initially.