[anyover88]

Any comments or tips are appreciated. I'm mostly just talking to myself here!

How does SHBG impact NBE?

From my understanding SHBG binds up free testosterone, meaning this could reduce circulating levels of testosterone that end up as DHT. However, this could also decrease estrogen, which is a double-edged sword. For someone that is estrogen dominant, maybe this is a good thing?

Diabetes and insulin resistance effect on SHBG

In people with insulin resistance or diabetes type 1 or 2, their SHBG levels are typically low, meaning that there will be more active free testosterone in the blood. If I am not mistaken this could probably manifest as high-test or estrogen dominance.

insulin resistance is obviously not a healthy condition, so healthy steps should be taken to correct that as well.

strategies for NBE with insulin resistance/diabetes

Note that a diabetic should be very aware of herbs that can lower blood glucose like Fenugreek and Licorice. However, according to this study it seems an herb like fenugreek can help with PCOS and insulin resistance:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813238/

anyway, a female with naturally high testosterone/estrogen and low SHBG could take herbs like saw palmetto, pygeum or reishi to prevent the free testosterone from turning into DHT.

The low SHBG state will leave a lot of free testosterone and estrogen floating around though. an herb that promotes aromatase like white peony may be optimal here, and will increase free estrogen.

so:

1) Reduce testosterone conversion to DHT
2) Convert excess testosterone to estrogen

obviously the above scenario is not ideal for the estrogen-dominant, so another option may be increasing SHBG and reducing estrogen.

These were listed in Lotus' supplement thread:

Hops-Activates alpha estrogen receptors which stimulates breast growth, increases SHBG which binds free testosterone

Flax-Phytoestrogen, increases SHBG, source of omega-3 fatty acids, Lignans (Flaxseed) are phytoestrogens with estrogenic or anti-estrogenic activity.

so:

1) Increase SHBG to lower testosterone -> Estrogen and testosterone -> DHT
2) Replace estrogen with phytoestrogen

hope this stuff makes sense

[Dynseli]

so:

1) Reduce testosterone conversion to DHT
2) Convert excess testosterone to estrogen

obviously the above scenario is not ideal for the estrogen-dominant, so another option may be increasing SHBG and reducing estrogen.

That's part of it, except in the case of estrogen dominance to influence proportionate amounts of (phyto) progesterone or prolactin. Progesterone and prolactin together lower and counter estrogen, and viceversa. They possibly break each other down into weaker, but effective hormones that don't bind to SHBG.

As for SHBG, insulin is the main thing to maintain.

[Lotus]

Sort of, increased SHBG:

Sex hormone-binding globulin (SHBG) is a glycoprotein synthesized by the liver. Circulating androgen and estrogen concentrations influence SHBG synthesis. The regulation of SHBG synthesis, combined with SHBG's higher affinity for testosterone, impacts bioavailable testosterone levels.

SHBG binds up to 98 percent of the steroid hormones in the blood including 5a-dihydrotestosterone (DHT), testosterone and androstenediol with particularly high affinity, and estradiol and estrone with slightly lower affinity

Male and female children have similar SHBG concentrations until the onset of puberty, when SHBG levels begin decreasing more rapidly in males than in females. Levels are higher in women than in men, due to the higher ratio of estrogens to androgens in women. Levels are especially elevated during late pregnancy and in women taking oral contraception.

Excellent info here:
http://www.digitalnaturopath.com/cond/C654345.html

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Estrogen, DHT and testosterone all compete inside the same cell receptor...SHBG a carrier protien but not active, the active carrier protien is albumin.

prostate androgen receptor and prostate-specific antigen secretion through the intermediacy of sex hormone-binding globulin.

Abstract
These experiments were designed to examine the relationship between the effects of steroid hormones mediated by classic intracellular steroid hormone receptors and those mediated by a signaling system subserved at the plasma membrane by a receptor for sex hormone-binding globulin. It is known that unliganded sex hormone-binding globulin (SHBG) binds to a receptor (RSHBG) on prostate membranes. The RSHBG.SHBG complex is rapidly activated by estradiol to stimulate adenylate cyclase, with a resultant increase in intracellular cAMP. In this paper we examine the effect of this system on a prostate gene product known to be activated by androgens, prostate-specific antigen. In serum-free organ culture of human prostates, dihydrotestosterone caused an increase in prostate specific antigen secretion. This event was blocked by the anti-androgens cyproterone acetate and hydroxyflutamide. In the absence of androgens, estradiol added to prostate tissue, whose RSHBG was occupied by SHBG, reproduced the results seen with dihydrotestosterone. Neither estradiol alone nor SHBG alone duplicated these effects. The estradiol.SHBG-induced increase in prostate-specific antigen was not blocked by anti-estrogens, but was blocked both by anti-androgens and a steroid (2-methoxyestradiol) that prevents the binding of estradiol to SHBG. Furthermore, an inhibitor of protein kinase A prevented the estradiol.SHBG-induced increase in prostate-specific antigen but not that which followed dihydrotestosterone. These data indicate that there is a signaling system that amalgamates steroid-initiated intracellular events with steroid-dependent occurrences generated at the cell membrane and that the latter signaling system proceeds by a pathway that involves protein kinase A.

http://www.ncbi.nlm.nih.gov/pubmed/9054366

[Lotus]

Hey there anyover88,

Maybe this can help?,

FAQ-NBE and Insulin Resistance
http://www.breastnexus.com/showthread.php?tid=20656

[Jeremyrip]

Hi all , just wondering if anyone on here could help me please , i have a minature whos insulin resistance , and just wondering if anybody else on here has one with the same problem and i was wondering what feeds you are using please,

thankyou

janette