[Lotus]

Grapefruit Juice

Something in grapefruit juice blocks the action of specific enzymes needed to absorb and break down drugs. These enzymes, found in the intestinal wall and liver, are called cytochrome P-450 3A4 and 1A2 (CYP3A4 and CYP1A2, for short). Several constituents of grapefruit juice have been implicated, including specific flavonoids and other phytochemicals called furanocoumarins. Concentration of these compounds varies from one batch of juice to another.

By inhibiting the action of these enzymes, grapefruit juice increases your body’s absorption of certain drugs, and also slows the process of breaking them down in the liver. Thus certain drugs affected by these enzymes stay in the body longer than normal.


You need to be well studied in your drug interactions when adding Grapefruit juice.


Quality clinical trials upon which to base therapeutic dosing recommendations are limited. Improved lipid profiles were achieved with consumption of 1 grapefruit daily for 30 days. Grapefruit juice 8 oz (237 mL), or half of a fresh grapefruit, 3 times a day before each meal for 12 weeks resulted in weight loss in a clinical trial evaluating the effect on metabolic syndrome. http://www.drugs.com/npp/grapefruit.html



Grapefruit Juice
http://www.pkdiet.com/pages/recipes/recipeiweb/recipe/Juice_Grapefruit.html