29-04-2010, 05:58
Actually, there is some misinformation here about grapefruit juice or grapefruit. It was discovered about 10 or so years ago when a Canadian doctor was trying to disguise the taste of a drug and chose GFJ as a mixer. It turned out that the GFJ acted as a booster for the drug. After some more research they determined that a chemical in it inhibited a certain enzyme in the gut which made an increase in the blood of the drug. Cytochrome P450 3A4 is also effected by many other things, caffeine, milk thistle, nicoteine, etc and it actually could work as a benefit because many of the herbs that you use for NBE are also effected by 3A4 inhibition, so if you are taking vitex, it could up the doseage and increase the bioavailablility of the important chemicals.
There are however, about 140 prescription drugs that can be adversely effected by GFJ so if you are on a PD, don't take GFJ without checking with the pharmacist. If you are on BCP, wait at least 4 hours after GFJ to take your pill as the effect, once thought to last 24 hours, has now been determined to last only 4 hours.
I was actually working on a longer explanation of this process and will post it as I get it done. This can actually be a useful tool in the bag of NBE'rs.
I drink it every day with my extracts or pills.
The other thing is, that like anything else, the individual may not see any results from including this drink. IT is all a matter of receptors, enzymes, and a myriad other things, and of course, that goes with NBE itself--some folks may never see anything simply because their physiology and genetics are sort of "tamper proof".
Also, most herbs are very low in dosage and clinical trials often use a great deal more, and then find no results. Red clover , for example,as sold, has about 2.5 mg of active ingredient and clinical trials used 40 to 80 mg daily over a 3 month period. So, you would have ton take 16 capsules a day to match that daily quantity of 40 mgs. Also, it's important to keep in mind time frames. Scientific trials are usually 3 months and longer and when they see no results, it likely means that for us on NBE, if after 3 months there is nothing, then it is time to change directions, herbs, or something.
There are however, about 140 prescription drugs that can be adversely effected by GFJ so if you are on a PD, don't take GFJ without checking with the pharmacist. If you are on BCP, wait at least 4 hours after GFJ to take your pill as the effect, once thought to last 24 hours, has now been determined to last only 4 hours.
I was actually working on a longer explanation of this process and will post it as I get it done. This can actually be a useful tool in the bag of NBE'rs.
I drink it every day with my extracts or pills.
The other thing is, that like anything else, the individual may not see any results from including this drink. IT is all a matter of receptors, enzymes, and a myriad other things, and of course, that goes with NBE itself--some folks may never see anything simply because their physiology and genetics are sort of "tamper proof".
Also, most herbs are very low in dosage and clinical trials often use a great deal more, and then find no results. Red clover , for example,as sold, has about 2.5 mg of active ingredient and clinical trials used 40 to 80 mg daily over a 3 month period. So, you would have ton take 16 capsules a day to match that daily quantity of 40 mgs. Also, it's important to keep in mind time frames. Scientific trials are usually 3 months and longer and when they see no results, it likely means that for us on NBE, if after 3 months there is nothing, then it is time to change directions, herbs, or something.