30-04-2010, 14:57
(This post was last modified: 30-04-2010, 14:59 by itsjust4fun91.)
2009 STUDY
excerpt
"Based upon extensive pharmacological research, scientists have established that grapefruit contains natural substances which can inhibit the activity of an enzyme system responsible for the metabolism of estrogen. If the normal metabolism process is affected, the result may be an increase in estrogen circulating in a woman’s body. Since estrogen is a well established risk factor for breast cancer, it is biologically plausible that regular intake of grapefruit can increase a woman’s risk of breast cancer.
We found considerable inter-individual variability between baseline hormone values and hormone values while consuming grapefruit. In comparing results for E1S, the change in hormone values after 24 hours of grapefruit intake ranges from -23% to +74% among study participants. In comparing results for E2, the change in hormone values after 24 hours of grapefruit intake ranges from -30% to +18% among study participants. We still have many analyses to do: to stratify by grapefruit product and to include adjustment factors in the model."
Full study can be found at the link above
Study 2007
excerpt
"It is interesting to note that the study found that grapefruit intake increased circulating estrogen levels in women not taking any hormones and in women who were on hormone therapy. This appears to indicate that grapefruit juice can affect not only the estrogens women produce naturally but those that they take to treat menopausal symptoms."
As before feel free to follow the link above the exerpt to read this study in full.
BBC NEWS
excerpt
"Previous studies have shown that a molecule called cytochrome P450 3A4 (CYP3A4) is involved in metabolising oestrogen hormones.
And grapefruit may boost blood oestrogen levels by inhibiting this molecule, allowing the hormones to build up."
excerpt
"Based upon extensive pharmacological research, scientists have established that grapefruit contains natural substances which can inhibit the activity of an enzyme system responsible for the metabolism of estrogen. If the normal metabolism process is affected, the result may be an increase in estrogen circulating in a woman’s body. Since estrogen is a well established risk factor for breast cancer, it is biologically plausible that regular intake of grapefruit can increase a woman’s risk of breast cancer.
We found considerable inter-individual variability between baseline hormone values and hormone values while consuming grapefruit. In comparing results for E1S, the change in hormone values after 24 hours of grapefruit intake ranges from -23% to +74% among study participants. In comparing results for E2, the change in hormone values after 24 hours of grapefruit intake ranges from -30% to +18% among study participants. We still have many analyses to do: to stratify by grapefruit product and to include adjustment factors in the model."
Full study can be found at the link above
Study 2007
excerpt
"It is interesting to note that the study found that grapefruit intake increased circulating estrogen levels in women not taking any hormones and in women who were on hormone therapy. This appears to indicate that grapefruit juice can affect not only the estrogens women produce naturally but those that they take to treat menopausal symptoms."
As before feel free to follow the link above the exerpt to read this study in full.
BBC NEWS
excerpt
"Previous studies have shown that a molecule called cytochrome P450 3A4 (CYP3A4) is involved in metabolising oestrogen hormones.
And grapefruit may boost blood oestrogen levels by inhibiting this molecule, allowing the hormones to build up."