[Dynsei]

Not permanently, but it might take a while, if not taking a break from progesterone. It probably depends on how much you take. If it goes beyond your comfort, or more than a month, take a break from progesterone cream, until menstruation starts (Don't atrophy the reproductive system). Everything goes back to normal afterwards. It's like how pregnancy raises prolactin and progesterone which signal the body to stop menstruating; after that everything returns to normal.