[Lotus]

Everyone should read this about Genistein, (one of phytoestrogens in PM and other products).

Also note that increased consumption of soy products reduces plasma concentrations of estradiol.

Genistein: does it prevent or promote breast cancer?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1638285/pdf/envhper00309-0057.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1638285/?page=1

From pg. 702 Possible Anti-Estrogenic Effects of Genistein

Genistein has significant estrogenic properties in both in vitro and in vivomodels (Table1). Genistein binds to the estrogen receptor(ER), although its binding affinity is several-fold weaker than that of estradiol(30). Genistein can also activate a number of estrogen-responsive genes in vitro, including pS2 and c-fos (18,31). Furthermore, when administered at low doses, genistein stimulates the growth of ER-positive(ER+) breast cancer cells (18-20). Findings in other tissue systems support the estrogenicity of genistein. For example, genistein is uterotrophic in a variety of species, resulting in impaired reproductive activity and increases inuterine wet weights.



Phytoestrogens and diseases of the prostate gland.
In particular, soya contains the isoflavone genistein, a compound with many properties which could influence both endocrine and growth factor signalling pathways.
http://www.ncbi.nlm.nih.gov/pubmed/?term=%5B10%5D%09+K%2C+Griffiths%2C+L.+Denis%2C+A.+Turkes%2C+et+al.%2C+“Phytoestrogens+and+Diseases+of+the+Prostate+Gland%2C”+Baillieres+Clinical+Endocrinology+Metabolism%2C+Vol.+12%2C+No.+4%2C+1998%2C+pp.+625-647.+doi%3A10.1016%2FS0950-351X(98)80008-6