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family history of ovarian cancer, should i take PM?

#7

I would highly recommend that you don't consider soy products at all. That goes for anyone who has fibrocystic breasts or has undergone a recent breast biopsy.


(20-08-2014, 00:26)Lotus Wrote:  
(19-08-2014, 22:08)Lotus Wrote:  Everyone should read this about Genistein, (one of phytoestrogens in PM and other products).

Also note that increased consumption of soy products reduces plasma concentrations of estradiol.

Genistein: does it prevent or promote breast cancer?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1638285/pdf/envhper00309-0057.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1638285/?page=1



From pg. 702 Possible Anti-Estrogenic Effects of Genistein

Genistein has significant estrogenic properties in both in vitro and in vivomodels (Table1). Genistein binds to the estrogen receptor(ER), although its binding affinity is several-fold weaker than that of estradiol(30). Genistein can also activate a number of estrogen-responsive genes in vitro, including pS2 and c-fos (18,31). Furthermore, when administered at low doses, genistein stimulates the growth of ER-positive(ER+) breast cancer cells (18-20). Findings in other tissue systems support the estrogenicity of genistein. For example, genistein is uterotrophic in a variety of species, resulting in impaired reproductive activity and increases inuterine wet weights.
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