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insulin resistance, diabetes and SHBG?
#1

Any comments or tips are appreciated. I'm mostly just talking to myself here!

How does SHBG impact NBE?

From my understanding SHBG binds up free testosterone, meaning this could reduce circulating levels of testosterone that end up as DHT. However, this could also decrease estrogen, which is a double-edged sword. For someone that is estrogen dominant, maybe this is a good thing?

Diabetes and insulin resistance effect on SHBG

In people with insulin resistance or diabetes type 1 or 2, their SHBG levels are typically low, meaning that there will be more active free testosterone in the blood. If I am not mistaken this could probably manifest as high-test or estrogen dominance.

insulin resistance is obviously not a healthy condition, so healthy steps should be taken to correct that as well.

strategies for NBE with insulin resistance/diabetes

Note that a diabetic should be very aware of herbs that can lower blood glucose like Fenugreek and Licorice. However, according to this study it seems an herb like fenugreek can help with PCOS and insulin resistance:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813238/

anyway, a female with naturally high testosterone/estrogen and low SHBG could take herbs like saw palmetto, pygeum or reishi to prevent the free testosterone from turning into DHT.

The low SHBG state will leave a lot of free testosterone and estrogen floating around though. an herb that promotes aromatase like white peony may be optimal here, and will increase free estrogen.

so:

1) Reduce testosterone conversion to DHT
2) Convert excess testosterone to estrogen

obviously the above scenario is not ideal for the estrogen-dominant, so another option may be increasing SHBG and reducing estrogen.

These were listed in Lotus' supplement thread:
Quote:Hops-Activates alpha estrogen receptors which stimulates breast growth, increases SHBG which binds free testosterone

Flax-Phytoestrogen, increases SHBG, source of omega-3 fatty acids, Lignans (Flaxseed) are phytoestrogens with estrogenic or anti-estrogenic activity.

so:

1) Increase SHBG to lower testosterone -> Estrogen and testosterone -> DHT
2) Replace estrogen with phytoestrogen


hope this stuff makes sense
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Messages In This Thread
insulin resistance, diabetes and SHBG? - by anyover88 - 16-11-2014, 22:46
RE: insulin resistance, diabetes and SHBG? - by Dynsei - 16-11-2014, 23:21
RE: insulin resistance, diabetes and SHBG? - by Lotus - 16-11-2014, 23:48
insulin resistance diabetes and SHBG - by Jeremyrip - 29-03-2015, 22:59



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