17-11-2014, 02:35
Since the topic of SHBG came up I'd like to share this excellent study on it:
![[Image: attachment.php?aid=8366]](http://www.breastnexus.com/attachment.php?aid=8366)
Steroid hormones exert a wide variety of effects on growth, development, and differentiation, including important regulatory and behavioral functions within the reproductive system, central nervous system, and adrenal axis. These hormones act by binding to specific intracellular receptor proteins that function as signal transducers and transcription factors to modulate expression of target genes.1,2 Molecular cloning of the steroid hormone receptor genes in humans has been accomplished over the past 15 years (Table 1). Sequence comparison has revealed that steroid hormone receptors belong to a diverse family of ligand-activated gene regulators that share a highly conserved structure and common mechanisms affecting gene transcription.3 The evolutionary relationship among the steroid and nuclear receptors has been deduced by the high conservation in their DNA-binding domains (DBDs) and in their less-conserved ligand-binding domains (LBDs) and indicates that this large group of proteins arose from a common ancestral molecule.3
Members of the Steroid Hormone and Nuclear Receptor Gene Superfamily in Mammalian Tissues
The Steroid Hormone Receptors
http://www.glowm.com/resources/glowm/cd/pages/v5/v5c004.html
Steroid hormones exert a wide variety of effects on growth, development, and differentiation, including important regulatory and behavioral functions within the reproductive system, central nervous system, and adrenal axis. These hormones act by binding to specific intracellular receptor proteins that function as signal transducers and transcription factors to modulate expression of target genes.1,2 Molecular cloning of the steroid hormone receptor genes in humans has been accomplished over the past 15 years (Table 1). Sequence comparison has revealed that steroid hormone receptors belong to a diverse family of ligand-activated gene regulators that share a highly conserved structure and common mechanisms affecting gene transcription.3 The evolutionary relationship among the steroid and nuclear receptors has been deduced by the high conservation in their DNA-binding domains (DBDs) and in their less-conserved ligand-binding domains (LBDs) and indicates that this large group of proteins arose from a common ancestral molecule.3
Members of the Steroid Hormone and Nuclear Receptor Gene Superfamily in Mammalian Tissues
The Steroid Hormone Receptors
http://www.glowm.com/resources/glowm/cd/pages/v5/v5c004.html