25-04-2015, 02:24
Research is like a box of chocolate, 
you never know what you'll get. 
SHBG secretes from the liver, and as we know SHBG is a transport protein (plasma) which then carries estrogens and androgens, albumin carries active hormones. The research states (SHBG-sex hormone binding globulin) could control local concentrations of SHBG in the breast and prostate, "thereby regulating RSHBG activation in an autocrine/paracrine manner". In other words quote- the local production of SHBG obtained with transfection could be a useful tool to control cell growth in estrogen-dependent breast cancer. This indicates SHBG can inhibit estradiol. (Now that's pretty cool).
Sex hormone-binding globulin, its membrane receptor, and breast cancer: a new approach to the modulation of estradiol action in neoplastic cells.
http://www.ncbi.nlm.nih.gov/pubmed/10419027?dopt=Abstract
The source of the SHBG that initializes RSHBG signaling in vivo is unclear; it could be taken up from the plasma, where it is relatively abundant, or synthesized in cells in which signaling occurs. In addition to the liver which is well known to be the source of plasma SHBG, and testis (which synthesizes the differentially glycosylated SHBG isoform, androgen binding protein (ABP), SHBG protein and mRNA have been demonstrated in other human tissues, including the prostate and breast [15-19]. The relatively stable concentration of plasma SHBG [20] makes it a less likely source for the initiation of RSHBG signaling, as the physiology of important signaling molecules depends on their variation with time. Other, more variable sources of SHBG would be better candidates. This raises the possibility that the prostate and breast themselves could control local SHBG concentrations, thereby regulating RSHBG activation in an autocrine/paracrine manner.
Human sex hormone-binding globulin gene expression- multiple promoters and complex alternative splicing http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694190/pdf/1471-2199-10-37.pdf
you never know what you'll get. SHBG secretes from the liver, and as we know SHBG is a transport protein (plasma) which then carries estrogens and androgens, albumin carries active hormones. The research states (SHBG-sex hormone binding globulin) could control local concentrations of SHBG in the breast and prostate, "thereby regulating RSHBG activation in an autocrine/paracrine manner". In other words quote- the local production of SHBG obtained with transfection could be a useful tool to control cell growth in estrogen-dependent breast cancer. This indicates SHBG can inhibit estradiol. (Now that's pretty cool).
Sex hormone-binding globulin, its membrane receptor, and breast cancer: a new approach to the modulation of estradiol action in neoplastic cells.
http://www.ncbi.nlm.nih.gov/pubmed/10419027?dopt=Abstract
The source of the SHBG that initializes RSHBG signaling in vivo is unclear; it could be taken up from the plasma, where it is relatively abundant, or synthesized in cells in which signaling occurs. In addition to the liver which is well known to be the source of plasma SHBG, and testis (which synthesizes the differentially glycosylated SHBG isoform, androgen binding protein (ABP), SHBG protein and mRNA have been demonstrated in other human tissues, including the prostate and breast [15-19]. The relatively stable concentration of plasma SHBG [20] makes it a less likely source for the initiation of RSHBG signaling, as the physiology of important signaling molecules depends on their variation with time. Other, more variable sources of SHBG would be better candidates. This raises the possibility that the prostate and breast themselves could control local SHBG concentrations, thereby regulating RSHBG activation in an autocrine/paracrine manner.
Human sex hormone-binding globulin gene expression- multiple promoters and complex alternative splicing http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694190/pdf/1471-2199-10-37.pdf