[AbiDrew85]

Oh, and for an idea of the toxicity potential of reishi:

https://www.researchgate.net/profile/Michael_Rieder/publication/5248831_Toxicity_of_a_traditional_Chinese_medicine_Ganoderma_Lucidum_in_children_with_cancer/links/0912f508a313fe7d2b000000.pdf

We already know reishi contains coumarins (albeit low concentrations).

The purpose of this study was to determine the effects of low and high concentrations of 3 different extracts of G. lucidum (GL, Reishi and PSGL) on the viability of 1) Jurkat E6.1 cells, 2) LG2 cells, and 3) peripheral blood mononuclear cells (PBMCs) isolated from a) healthy adults, b) healthy children, and c) paediatric patients undergoing chemotherapy. We hypothesize that at low concentrations (1 – 30 μg/mL), extracts of G. lucidum will stimulate cells of the immune system, and at high concentrations (200 – 350 μg/mL), extracts of G. lucidum will cause toxicity in cells of the immune system.

Right. And those were targeted extracts containing only the anti-cancer actives, so even the anti-cancer actives can become toxic.

Coumarin is moderately toxic to the liver and kidneys, with a median lethal dose (LD50) of 275 mg/kg, a low toxicity compared to related compounds. Though it is only somewhat dangerous to humans, coumarin is hepatotoxic in rats, but less so in mice.

It actually takes MORE coumarin than the anti-cancer actives in reishi extracts targeted towards anti-cancer to reach toxic levels. Almost anything can become toxic at high enough levels, even water. My point is that the anti-androgen in reishi IS the coumarin, and it's very low concentration compared to things with much higher toxicity. That's why I discarded reishi as an anti-androgen in my own research. I'm not saying reishi isn't great to use for its other properties, just that it's very poor to use for anti-androgen.

nightgazer12, I think I was probably the one who said something like that once upon a time. Though that was before I did more research and realized that the two actives in chinese skullcap while working at the target point I talked about, only reached about 50% total efficacy. So it only blocks half of your testosterone production on its own, and at rather high doses. Those doses are safe though, chinese skullcap is incredibly safe. It just gets pricier than you might expect due to the high doses. You also need to not be squeamish about taking fistfuls of pills. Because you literally would be taking fistfuls of capsules of chinese skullcap alone to reach a 50% reduction in testosterone from chinese skullcap.