27-04-2016, 20:35
Yup, I get all that. Coumarins are in a variety of NBE herbs (PM too). What I don't get is saying coumarins cause toxicity but you suggest finding a Purer (higher?) form.
rarity of liver toxicity in patients treated with coumarin (1,2-benzopyrone).
Cox D, et al. Hum Toxicol. 1989.
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Abstract
1. Two thousand, one hundred and seventy-three patients with cancer or chronic infections were treated with coumarin in a clinical trial. 2. 0.37% of these patients developed elevated liver enzyme levels during therapy with coumarin. 3. This hepatitis was probably a form of idiosyncratic hepatotoxicity and may have been immune in origin.
I suggest reading this study:
Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772644/
rarity of liver toxicity in patients treated with coumarin (1,2-benzopyrone).
Cox D, et al. Hum Toxicol. 1989.
Show full citation
Abstract
1. Two thousand, one hundred and seventy-three patients with cancer or chronic infections were treated with coumarin in a clinical trial. 2. 0.37% of these patients developed elevated liver enzyme levels during therapy with coumarin. 3. This hepatitis was probably a form of idiosyncratic hepatotoxicity and may have been immune in origin.
I suggest reading this study:
Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772644/