(27-04-2016, 20:35)Lotus Wrote: Yup, I get all that. Coumarins are in a variety of NBE herbs (PM too). What I don't get is saying coumarins cause toxicity but you suggest finding a Purer (higher?) form.
Purer as in just coumarin as the only active, no other actives, including coumarin derivatives.
(27-04-2016, 20:35)Lotus Wrote: rarity of liver toxicity in patients treated with coumarin (1,2-benzopyrone).
Cox D, et al. Hum Toxicol. 1989.
Show full citation
Abstract
1. Two thousand, one hundred and seventy-three patients with cancer or chronic infections were treated with coumarin in a clinical trial. 2. 0.37% of these patients developed elevated liver enzyme levels during therapy with coumarin. 3. This hepatitis was probably a form of idiosyncratic hepatotoxicity and may have been immune in origin.
I would certainly be interested in seeing full text for this research, but it doesn't seem to be available even if you are willing to pay for it, not that I could. EDIT: 0.37% is low enough to be in line with the potential for compromised guts to play a role.
(27-04-2016, 20:35)Lotus Wrote: I suggest reading this study:
Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772644/
I have. It says nothing about coumarin itself other than that all these others are derived from it. It does mention the tonka bean as a rich source of "coumarins". But if you do research on the tonka bean you'll find that uncontaminated tonka bean is indeed a rich source of coumarin. ONLY coumarin, no derivatives unless contaminated by bacteria.