27-04-2016, 21:20
Lol, you want me to provide (and pay) all the research, too funny.
Endogenous estrogens have an important role not only in the hypothalamic-pituitary-gonadal axis, but also in various non-gonadal systems, such as cardiovascular systems, bone, and central nervous systems, and lipid metabolism.
Usui T. Endocr J. 2006.
Coumarin based selective estrogen receptor modulators (SERMs) and coumarin-estrogen conjugates have also been described as potential antibreast cancer agents.
I see coumarins having weak estrogenic potential, (and modulating HPA, SERMS, as stated), I'd like to see you're research on coumarins having anti-androgens properties (I know it does, still, (I'm curios) what you have. There's a lot more to that study then a quick glance of 103 pages. e.g:
For example, coumarin and its active metabolite, 7-hydroxycoumarin, demonstrated growth-inhibitory cytostatic activity in human cancer cell lines, such as A549 (lung), ACHN (renal), H727 (lung), MCF-7 (breast) and HL-60 (leukemia), and have also been reported to demonstrate activity against prostate cancer, malignant melanoma, and metastatic renal cell carcinoma in clinical trials [26–29]
Endogenous estrogens have an important role not only in the hypothalamic-pituitary-gonadal axis, but also in various non-gonadal systems, such as cardiovascular systems, bone, and central nervous systems, and lipid metabolism.
Usui T. Endocr J. 2006.
Coumarin based selective estrogen receptor modulators (SERMs) and coumarin-estrogen conjugates have also been described as potential antibreast cancer agents.
I see coumarins having weak estrogenic potential, (and modulating HPA, SERMS, as stated), I'd like to see you're research on coumarins having anti-androgens properties (I know it does, still, (I'm curios) what you have. There's a lot more to that study then a quick glance of 103 pages. e.g:
For example, coumarin and its active metabolite, 7-hydroxycoumarin, demonstrated growth-inhibitory cytostatic activity in human cancer cell lines, such as A549 (lung), ACHN (renal), H727 (lung), MCF-7 (breast) and HL-60 (leukemia), and have also been reported to demonstrate activity against prostate cancer, malignant melanoma, and metastatic renal cell carcinoma in clinical trials [26–29]