04-05-2016, 02:53
An excellent study here:
The Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals
http://m.toxsci.oxfordjournals.org/content/94/1/3.full.pdf
Steroid hormone synthesis is controlled by the activity of several highly substrate-selective cytochrome P450 enzymes and a number of steroid dehydrogenases and reductases. Particularly aromatase (CYP19), the enzyme that converts androgens to estrogens, has been the subject of studies into the mechanisms by which chemicals interfere with sex steroid hormone homeostasis and function, often related to (de)feminization and (de)masculinazation processes.
The Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals
http://m.toxsci.oxfordjournals.org/content/94/1/3.full.pdf
Steroid hormone synthesis is controlled by the activity of several highly substrate-selective cytochrome P450 enzymes and a number of steroid dehydrogenases and reductases. Particularly aromatase (CYP19), the enzyme that converts androgens to estrogens, has been the subject of studies into the mechanisms by which chemicals interfere with sex steroid hormone homeostasis and function, often related to (de)feminization and (de)masculinazation processes.