[Lotus]

I'm currently researching the link between antidepressant fluoxetine and the actions this molecule influences on allopreneglalone, which is a byproduct of progesterone, and the relationship between NBE.

allopregnanolone (ALLO) and Tetrahidroteoxicorticosterone (THDOC), which are isoforms of the enzyme 5 alpha reductase.

Here's some information from a blogger about Finasteride (btw, excellent work by the blogger, link is posted below). One important distinction about Finasteride is in the highlighted text, perhaps mediating GABA-A modulation is something worth looking into.

allopregnanolone (ALLO) and Tetrahidroteoxicorticosterone (THDOC)
(allosteric modulators) of GABA-A receptors,

The way finasteride causes post finasteride syndrome in certain individuals is unknown. Finasteride blocks the conversion of testosterone to dihydrotestosterone (DHT), but also causes changes in testosterone levels, LH and FSH. 1 Finasteride also blocks the biosynthesis of various neuro steroids such as allopregnanolone (ALLO) and Tetrahidroteoxicorticosterone (THDOC), which are isoforms of the enzyme 5 alpha reductase. ALLO and THDOC are positive modulators (allosteric modulators) of GABA-A receptors, which have the same mechanism of action of anxiolytic drugs such as benzodiazepines. 2, 3 Finasteride has been shown to inhibit the biosynthesis of these neuro steroids, which can be one of the causes for the emotional and sexual symptoms reported. 4 However, some symptoms, such as muscle wasting, loss of body hair and the continuation of symptoms long after the medication has been discontinued, have not been explained yet. Because some patients with SPF have normal or high levels of testosterone - but at the same time a complete clinical state of hypogonadism - it has been hypothesized that these individuals have developed a form of resistance to androgen hormones.

More HrT info here:
http://www.breastnexus.com/showthread.php?tid=23606