[NaturalLady31]

Good one, Bettie! I too have always read that we need much more omega 3's.    I'm not keen on the idea of ramping up anything that could promote inflammation (who would want to??)

This is true.....there is no earthly benefit to systemic inflammation...especially when most major illness comes from the inflammation in cells (in other words, proliferation). The 1:1 ratio is ideally synergistic for all things considered (e.g. mRNA, DNA synthesis....and the mitochondrial matrix).

good point Bettie.

Thank you Lotus, NaturalLady and Surferjoe.

Exactly Lotus, 1:1 ratio is healthier and safer. It makes more sense. Not sure who on earth came up with the 4:1 ratio and why he/she thinks inflammation is good...

Now, I still want to continue taking EPO (omega 6), low dose, because it's good for PMS, PCOS and maybe even NBE (being a pro-aromatase) so I thought, "Ok, I'll just take more omega 3 in the form of krill oil/fish oil" (as you mentioned NaturalLady). But this raises another issue/mystery. Is fish oil good or bad for NBE?? What do you think, Lotus? Some sources (and members on here too) state that fish oil raises testosterone (yikes). There are quite a few threads and debates about this. Here's one: http://www.breastnexus.com/showthread.php?tid=7774 

I actually have a feeling fish oil could raise testosterone, but I'm not sure. I'm not willing to experiment lol If this is true, which component/substance in fish oil raises T? Is it the DHA? I hope it's not the omega 6, which we need (not only for NBE but for overall health!). Is there a solution (omega 6 source that doesn't inhibit NBE, if this is true)?

I believe n-3 PUFAs can displace n-6 PUFAs, in other words improving the omega 3 index not only improves insulin resistance but lowers (or prevents) the symptoms of PCOS....which PCOS is driven by impaired insulin production. I also found the higher ratio of n-6 PUFAs over omega 3's can contribute to higher pool androgen levels. 

Hormonal and metabolic effects of polyunsaturated fatty acids in young women with polycystic ovary syndrome: results from a cross-sectional analysis and a randomized, placebo-controlled, crossover trial1–4 
http://ajcn.nutrition.org/content/93/3/652.full.pdf

Is fish oil ok for NBE?.....possibly, personally I prefer krill oil over fish oil.....krill is said to be 48 times stronger than fish oil. 

Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil
 
https://www.ncbi.nlm.nih.gov/pmc/article...12-178.pdf

Btw, myo-inositol improves PCOS too, and inositol is pro-aromatase.

https://www.ncbi.nlm.nih.gov/pubmed/27898267
http://onlinelibrary.wiley.com/doi/10.10...2/abstract

Another benefit for improving the omega 3 index (for NBE) it's this....higher androgen index produces increased luteinizing hormone (LH) secretion, which produces androstenedione, and A4 (Δ4 dione) indirectly produces E2 (estradiol) by way of aromatase. (another example please see DHEA study):

DHEA metabolites activate estrogen receptors alpha and beta
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529809/

Speaking of Aromatase: I've listed the info a couple of times, but retinoids (vitamin A) are pro-aromatase too. 

Retinoic acids promote the action of aromatase and 17beta-hydroxysteroid dehydrogenase type 1 on the biosynthesis of 17beta-estradiol in placental cells.
https://www.ncbi.nlm.nih.gov/pubmed/1178...t=Abstract

Thanks to Zara and Lotus for chiming in here with good info!  Bettie, looks like you're already doing good things regarding PCOS and aromatase, so that's encouraging!

Thanks for helping bring some clarity to these omega questions. It seems that we don't need to shy away from 3's.  And it also sounds like if we focus on promoting aromatase, the possible increase in androgens from omega 3's would be a non-issue.