Consider the female case outlined in the Wikipedia article on estrogen insensitivity syndrome:
Look at her photo: neither breast nor nipple nor areolar development. Even her skeletal habitus is male. If we consider XY males with complete androgen insensitivity syndrome, we find their outward appearance to be almost indistinguishable from XX females. They tend to have lovely faces, and their breasts are well-developed.
I believe cases of poor breast development in the presence of adequate hormones are caused by regional insensitivity to gonadotropic and corticotropic steroids, among other things. I believe that persistently focusing on raising global steroid levels while not addressing tissue sensitivity is dangerous, as it increases the risk of experiencing the harmful effects of imbalanced and continually elevated gonadotropins while inviting one on a perpetual goose chase whose only reward is sorrow.
Quote:In 2013, an 18-year-old woman with EIS was reported... The patient presented with delayed puberty, including an absence of breast development (Tanner stage I) and primary amenorrhea, as well as intermittent pelvic pain... Estrogen levels were dramatically and persistently elevated (estradiol levels were 2,340 pg/mL, regarded as being about 10 times the normal level, and ranged from 750–3,500 pg/mL), gonadotropin levels were mildly elevated (follicle-stimulating hormone and luteinizing hormone levels were 6.7–19.1 mIU/mL and 5.8–13.2 mIU/mL, respectively), and testosterone levels were slightly elevated (33–88 ng/dL).
Look at her photo: neither breast nor nipple nor areolar development. Even her skeletal habitus is male. If we consider XY males with complete androgen insensitivity syndrome, we find their outward appearance to be almost indistinguishable from XX females. They tend to have lovely faces, and their breasts are well-developed.
I believe cases of poor breast development in the presence of adequate hormones are caused by regional insensitivity to gonadotropic and corticotropic steroids, among other things. I believe that persistently focusing on raising global steroid levels while not addressing tissue sensitivity is dangerous, as it increases the risk of experiencing the harmful effects of imbalanced and continually elevated gonadotropins while inviting one on a perpetual goose chase whose only reward is sorrow.