02-11-2019, 08:49
(02-11-2019, 04:17)Bonny Wrote:(02-11-2019, 02:27)TallyHo Wrote: Consider the female case outlined in the Wikipedia article on estrogen insensitivity syndrome:
Quote:In 2013, an 18-year-old woman with EIS was reported... The patient presented with delayed puberty, including an absence of breast development (Tanner stage I) and primary amenorrhea, as well as intermittent pelvic pain... Estrogen levels were dramatically and persistently elevated (estradiol levels were 2,340 pg/mL, regarded as being about 10 times the normal level, and ranged from 750–3,500 pg/mL), gonadotropin levels were mildly elevated (follicle-stimulating hormone and luteinizing hormone levels were 6.7–19.1 mIU/mL and 5.8–13.2 mIU/mL, respectively), and testosterone levels were slightly elevated (33–88 ng/dL).
Look at her photo: neither breast nor nipple nor areolar development. Even her skeletal habitus is male. If we consider XY males with complete androgen insensitivity syndrome, we find their outward appearance to be almost indistinguishable from XX females. They tend to have lovely faces, and their breasts are well-developed.
I believe cases of poor breast development in the presence of adequate hormones to be caused by regional insensitivity to gonadotropic and corticotropic steroids, among other things. I believe that persistently focusing on raising global steroid levels while not addressing tissue sensitivity is dangerous, as it increases the risk of experiencing the harmful effects of imbalanced and continually elevated gonadotropins while inviting one on a perpetual goose chase whose only reward is sorrow.
"Estrogen insensitivity syndrome (EIS), or estrogen resistance, is a form of congenital estrogen deficiency or hypoestrogenism[2]which is caused by a defective estrogen receptor (ER) – specifically, the estrogen receptor alpha (ERα) – that results in an inability of estrogen to mediate its biological effects in the body" - Wikipedia
So back to pondering - Tallyho Wikipedia article show a 10x normal level of E, along with elevation on other hormones however no breast development Tanner 1, so if E is the magic key then wheres the breast development? Without a sensitive E receptor there is none....
TallyHo how to resensitize your receptors? My list of info ive gathered along the way things that help receptors...for more details on the what/how I'd need to backtrack into nbe research. But for now I'll mention them;
- Dandelion tea
- Progesterone cream
- Vanilla
- Dont overload on hormones as causes receptor become desensitized, should be no.1 more is not better!
Please add more if know of some!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823379/
I just had a a look at the same case study!
What I found in this case there are lots of connections with other things than mere gene mutation, like both male female case study ( those with hormonal insensitivnes) insulin resistance!! Male was obese and female was low BMI. Two extremes of insulin resistance appearance! Also when they treated girl with estrogen no breast growth was reported! But she got some improvements with her multicystic ovaries! Unfortunately they did not treated her with progesterone!
So what I conclude is low fat high carb diet is making us insulin resistance thereby estrogen insensitiveness! Also I had look at lots of before and after pictures of keto diet! All women got very nice breast compared to their previous picture!! So we need increase our fat intake and also decrease our bad carb/sugar.