(22-05-2014, 04:59)lovely11 Wrote: fenugreek will work and is pretty safe. red clover won't. red clover's phytoestrogens (it works on ER-beta) don't interact with receptors in the breast (ER-alpha, PR, PrlR) . also, there's evidence that red clover can cause permanent infertility. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963458/
Actually, it's both receptors, here's a 2009 study, (some evidence states its preferential to ER-ß).
Red Clover isoflavones possess varying affinity for estradiol receptors (estradiol-α and estradiol-β),
capable of acting as both agonists and antagonists (20). Preliminary evidence suggests a preferential
binding to estrogen receptor β, which is found in the vasculature, brain, bone, and heart, as opposed to
estrogen receptor α (found in the ovaries, breast, uterus, and adrenal glands). Concomitant use of red
clover may enhance or inhibit the estrogenic effects of hormonal therapies. Isoflavones may affect
levels of gonadotropin releasing hormone (GrRH), follicle stimulating hormone (FSH), and leutinizing
hormone (LH) via hormonal feedback mechanisms (10).
http://www.natrodale.co.za/uploads/Natro...Clover.pdf