[Lotus]

Dear lotus I love you this is sooooo helpful C; a very happy rocket wishes you a good day haha c;

Lol thanks rocket, I feel the love and back at ya gorgeous.

So what's up girl?, you've been quiet lately. It's good to hear from you and I hope all is well with you.

[Candace]

The study you mention states this:

(Same study, different reporting source)
Medscape Medical News
Mucuna pruriens Seed May Be Helpful in Long-term Management of Parkinson's Disease:

These findings suggest that M pruriens formulations may actually have a higher bioavailability than standard L-dopa preparations.... If these findings can be confirmed in larger and longer term studies, mucuna would seem to be a reasonable commercially viable alternative to standard L-dopa."

Like I said before, this is irrelevant to everyone reading this forum. L-DOPA and mucuna are two things that are reasonable to take if and only if one has Parkinson's that is no longer treatable with NMDA antagonists, dopamine receptor agonists, and/or MAOB inhibitors. That is because mucuna causes the same dyskinesias as L-DOPA.

[Lotus]

Thanks Lotus!
I've decided to add Vitamin E, C and Fenugreek and also start taking MSM throughout since I read it helps to stimulate collagen production and has great benefits for growing hair since I'm trying to grow mine out anyways!
I do have another question! During my follicular phase, I am currently taking PM, Wild Yam and calcium (to help PM absorb better). I will be adding in MSM once it arrives .. but are there any other complimenting herbs that I could add in or should I stick to this?
Thank you for your help, you are a star!

Hi Skeeeee, (thanks)

If you keep those herbs at reasonable levels I would consider some fennel, whole grains, healthy fats, and even some dark chocolate is actually ok (limit other caffeine intake though).

Other suggestions- drink plenty of filtered water, exercise and massage.

[Lotus]

Omg!Thanks Lotus!Im going to add vitamin E to my regimen and take 400 IU of it...now the question is...how should I cycle it?

Hi Wanna pear shape, Here's some interesting info on vitamin E, (when to cycle isn't vey clear).

The Effect of Vitamin E on Breast Lumps,
Vitamin E might have an effect on the hormones that control breast growth, and may therefore play a role in fibrocystic change. One of the major hormones that governs breast growth is estrogen, which triggers the proliferation of the cells that make up breast glandular tissue. A study published in "Nutrition and Cancer" in 2005 indicates that vitamin E may affect how your breast cells respond to estrogen, and might inhibit breast growth upon exposure to estrogen. While the specific role of vitamin E in fibrocystic change has not yet been fully explored, this may explain why the vitamin acts as an effective treatment for the disorder in some women.
http://www.livestrong.com/article/475278...ast-lumps/


Novel interactions of vitamin E and estrogen in breast cancer.
The prevention of breast cancer through dietary modification is an active area of clinical and epidemiological research. It has been proposed that dietary supplementation of vitamin E may reduce a woman's risk of developing breast cancer. However, the exact mechanism remains unknown. alpha-Tocopherol is the most biologically active form of vitamin E. We investigated the effect of vitamin E (alpha-tocopherol) on breast cancer cell growth. A dose-dependent inhibition of cell proliferation was found in estrogen receptor (ER)-positive cells showing a potent suppression of growth at 100 microM vitamin E in MCF-7 (53%) and T47D (75%) cells. Vitamin E reduced significantly the response of both cell lines to estrogen (10 nM), and cell proliferation was decreased in MCF-7 and T47D cells by 69% and 84%, respectively. No growth inhibition was observed when cells were grown in the absence of estrogen. Vitamin E altered and decreased the growth inhibition induced by tamoxifen (10 microM) in MCF-7 (33%) and T47D (54%) cells. In addition, the immunostaining of ER of MCF-7 cells was reduced by 30% in the presence of vitamin E, suggesting an effect of vitamin E on the expression of ER. This provides evidence that vitamin E may inhibit ER-positive cell growth by altering the cellular response to estrogen.
http://www.ncbi.nlm.nih.gov/pubmed/16091003

Are Specific Vitamins Good for Breast Growth?
Vitamin E is a fat-soluble antioxidant that boosts immune system function and protects your breasts from cellular damage, according to Steve Blake, author of the book “Vitamins and Minerals Demystified.” Blake explains that vitamin E also supports muscle health, decreases inflammation in your body, promotes breast development, heals damaged tissues, strengthens blood vessels and carries nutrients to your breast tissues. The recommended daily dosage for vitamin E is 15 milligrams for adults. Foods rich in vitamin E include sunflower seeds, spinach, tomatoes, broccoli, soybeans, corn oil, hazelnuts, peanut butter and almonds.
http://www.livestrong.com/article/383485...st-growth/


Recommended daily intake of vitamins and minerals-
Vitamin E (tocopherol)
Vitamin E in food and as a supplement larger than 1000 mg cause blood clotting, which results in increased likelihood of haemorrhage in some individuals
Read more: http://www.lenntech.com/recommended-dail...z3CbcE9dHX

However mayo clinic states this: For leg pain due to clogged arteries, 300-1,600 milligrams of Vitamin E has been taken by mouth daily for up to 18 months.
http://www.mayoclinic.org/drugs-suppleme...b-20060476


Vitamin E Fact Sheet for Health Professionals
http://ods.od.nih.gov/factsheets/Vitamin...ional/#en6
Naturally occurring vitamin E exists in eight chemical forms (alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol) that have varying levels of biological activity [1]. Alpha- (or α-) tocopherol is the only form that is recognized to meet human requirements.

gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention
http://www.ncbi.nlm.nih.gov/pubmed/11722951

These distinguishing features of gamma-tocopherol and its metabolite suggest that gamma-tocopherol may contribute significantly to human health in ways not recognized previously. This possibility should be further evaluated, especially considering that high doses of alpha-tocopherol deplete plasma and tissue gamma-tocopherol, in contrast with supplementation with gamma-tocopherol, which increases both. We review current information on the bioavailability, metabolism, chemistry, and nonantioxidant activities of gamma-tocopherol and epidemiologic data concerning the relation between gamma-tocopherol and cardiovascular disease and cancer.

[Candace]

Vitamin E in food and as a supplement larger than 1000 mg cause blood clotting, which results in increased likelihood of haemorrhage in some individuals
Read more: http://www.lenntech.com/recommended-dail...z3CbcE9dHX

Just a minor quibble - vitamin E can interfere with blood clotting, not cause it. The conclusion is correct: increased hemorrhage risk. It's thought to be because it either interferes with vitamin K metabolism or it stimulates the degradation of K. MK-7 is the most effective form of vitamin K because it has the longest half-life in the blood and vitamin K uptake by tissues from blood is relatively slow.

[skyeeeee]

Thanks Lotus!
I shall add in some Fennel and see how things go
Youre amazing ^^

[Candace]

I looked into the other things on the anti-prolactin list and think that licorice, goldenseal, ginger, and vitamin B6 should also be removed.

Licorice is effective, but not safe enough. It is a monoamine oxidase A inhibitor, which can cause lethal hypertensive crisis if you eat foods containing tyramine. (The abstract doesn't specifically say MAOAI, but since licorice elevated norepinephrine you have to come to that conclusion because MAOBI's only raise dopamine.) In medicine, MAOAI's have been replaced by SSRI's and SNRI's to avoid killing people. Licorice's effects on cortisol and gap junction intercellular communication are two more strikes against it.

I could not find any evidence that goldenseal or ginger affect prolactin. Vitamin B6 is unreliable, and the effective dose (200-600 mg) is in the toxic range. (The upper limit for B6 is 100 mg.)

[Lotus]

I looked into the other things on the anti-prolactin list and think that licorice, goldenseal, ginger, and vitamin B6 should also be removed.

Vitamin B6 is unreliable[/url], and the effective dose (200-600 mg) is in the toxic range. (The upper limit for B6 is 100 mg.)

Who's suggesting taking the upper limit's?, the research is clearly out there.

Certain medications interfere with the metabolism of vitamin B6; therefore, some individuals may be vulnerable to a vitamin B6 deficiency if supplemental vitamin B6 is not taken. In the NHANES 2003-2004 analysis, significantly more current and past users of oral contraceptives (OCs) among menstruating women had low plasma PLP levels compared to women who have never used OCs, suggesting that the estrogen content of OCs may interfere with vitamin B6 metabolism (see Side effects of oral contraceptives below) (88). Anti-tuberculosis medications (e.g., isoniazid and cycloserine), the metal chelator penicillamine, and anti-parkinsonian drugs like L-Dopa can all form complexes with vitamin B6 and limit its bioavailability, thus creating a functional deficiency. PLP bioavailability may also be reduced by methylxanthines, such as theophylline used to treat certain respiratory conditions (7). The long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs; e.g. celecoxib and naproxen) may also impair vitamin B6 metabolism (91). Conversely, high doses of vitamin B6 have been found to decrease the efficacy of two anticonvulsants, phenobarbital and phenytoin, and of L-Dopa. (6, 90).

http://lpi.oregonstate.edu/infocenter/vitami


Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects].
http://www.ncbi.nlm.nih.gov/pubmed/?term=6324828


Effect of clonidine on growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and thyroid-stimulating hormone in the serum of normal men.
http://www.ncbi.nlm.nih.gov/pubmed/1184719

Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise.
http://www.ncbi.nlm.nih.gov/pubmed/7088124


Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects].
http://www.ncbi.nlm.nih.gov/pubmed/6324828

Nutritionally relevant supplementation of vitamin B6 in lactating women: effect on plasma prolactin.
http://www.ncbi.nlm.nih.gov/pubmed/4058985

Effect of pyridoxine on plasma levels of HGH, PRL, and TSH in normal women
http://www.ncbi.nlm.nih.gov/pubmed/358720


Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion.
http://www.ncbi.nlm.nih.gov/pubmed/16690808

[Candace]

Who's suggesting taking the upper limit's?, the research is clearly out there.

I haven't found any evidence that B6 will lower prolactin at doses lower than 200 mg, which is twice the upper limit. Looking through your references, we have

1. 600 mg B6 worked.
2. Clonidine had no effect. B6 is not mentioned.
3. An unspecified dose of B6 worked. Have you seen the full text for details?
4. Duplicate of reference #1.
5. 4 mg B6 was ineffective.
6. An unspecified dose of B6 didn't work.
7. A concentration of 100 micromoles/liter B6 worked in vitro. It would take a toxic dose to get that concentration in the body. 400 mg B6/day only gets you to a maximum of 0.69 micromoles/liter and that is by no means assured. Looking at Table 1 at the end, the other treatment group only got to a maximum of 0.48 micromoles/liter, and that was at 300 mg/day. At 400 mg/day they dropped a bit to 0.45.

[Lotus]

Beneficial influences of Estrogen Metabolism-





Nutritional Influences on Estrogen Metabolism
http://www.afmcp-sa.com/ansr/MET451%20En...20ANSR.pdf