[Bloom]

Can someone please explain cycling. I understand the concept but lack the basics. ie, when to start, when to stop, .ect.

[Lotus]

Hi Bloom,

Cycling would be to address estrogen dominance and to spare the liver from toxicity, (other reasons listed below).

when to start, when to stop, .ect.

The bottom line is to have your hormones in balance before starting an NBE program, otherwise it's money down the drain trying to play catch up balancing out of whack hormones. Monitor symptoms, e.g. mood, weight gain, acne, excessive bleeding, insomnia etc. to gauge when to cycle.

Why increasing the dosage doesn't always work

Negative feedback occurs when the result of a process influences the operation of the process itself in such a way as to reduce changes. Feedback can produce stability and reduce the effect of fluctuations. Negative feedback loops in which just the right amount of correction is applied in the most timely manner can be very stable, accurate, and responsive.

Negative feedback loops have been compared to a thermostatically controlled temperature in a house, where the internal temperature is monitored by a temperature-sensitive gauge in the thermostat. If it is cold outside, eventually the internal temperature of the house drops, as cold air seeps in through the walls. When the temperature drops below the point at which the thermostat is set, the thermostat turns on the furnace. As the temperature within the house rises, the thermostat again senses this change and turns off the furnace when the internal temperature reaches the pre-set point.

Negative feedback loops require a receptor, a control center, and an effector. A receptor is the structure that monitors internal conditions. For instance, the human body has receptors in the blood vessels that monitor the pH of the blood. The blood vessels contain receptors that measure the resistance of blood flow against the vessel walls, thus monitoring blood pressure. Receptors sense changes in function and initiate the body's homeostatic response.

The important thing to remember here is this:

A target cell may have between 2,000 and 100,000 receptors for a particular hormone.

Receptors, like other cellular proteins, are constantly being synthesized and broken down. Here's an important (pro active) step:

CYCLE YOUR NBE PROGRAMS WITH BREAKS!

Tolerance occurs when the person no longer responds to the drug in the way that person initially responded. Stated another way, it takes a higher dose of the drug to achieve the same level of response achieved initially.

Some drugs require a period of abstinence periodically to allow the cell to return to normal receptor density.

A more technical version,

Hormones that bind to plasma membrane receptors can induce their effects at very low concentrations because they initiate a cascade or chain reaction.

Hormones affect distant cells by binding to specific receptor proteins in the target cell resulting in a change in cell function. When a hormone binds to the receptor, it results in the activation of a signal transduction pathway. This may lead to cell type-specific responses that include rapid non-genomic effects or slower genomic responses where the hormones acting through their receptors activate gene transcription resulting in increased expression of target proteins.

[Bloom]

Hi Bloom,

Cycling would be to address estrogen dominance and to spare the liver from toxicity, (other reasons listed below).

when to start, when to stop, .ect.

The bottom line is to have your hormones in balance before starting an NBE program, otherwise it's money down the drain trying to play catch up balancing out of whack hormones. Monitor symptoms, e.g. mood, weigh gain, acne, excessive bleeding, insomnia etc. to gauge when to cycle.

Why increasing the dosage doesn't always work

Negative feedback occurs when the result of a process influences the operation of the process itself in such a way as to reduce changes. Feedback can produce stability and reduce the effect of fluctuations. Negative feedback loops in which just the right amount of correction is applied in the most timely manner can be very stable, accurate, and responsive.

Negative feedback loops have been compared to a thermostatically controlled temperature in a house, where the internal temperature is monitored by a temperature-sensitive gauge in the thermostat. If it is cold outside, eventually the internal temperature of the house drops, as cold air seeps in through the walls. When the temperature drops below the point at which the thermostat is set, the thermostat turns on the furnace. As the temperature within the house rises, the thermostat again senses this change and turns off the furnace when the internal temperature reaches the pre-set point.

Negative feedback loops require a receptor, a control center, and an effector. A receptor is the structure that monitors internal conditions. For instance, the human body has receptors in the blood vessels that monitor the pH of the blood. The blood vessels contain receptors that measure the resistance of blood flow against the vessel walls, thus monitoring blood pressure. Receptors sense changes in function and initiate the body's homeostatic response.

The important thing to remember here is this:

A target cell may have between 2,000 and 100,000 receptors for a particular hormone.

Receptors, like other cellular proteins, are constantly being synthesized and broken down. Here's an important (pro active) step:

CYCLE YOUR NBE PROGRAMS WITH BREAKS!

Tolerance occurs when the person no longer responds to the drug in the way that person initially responded. Stated another way, it takes a higher dose of the drug to achieve the same level of response achieved initially.

Some drugs require a period of abstinence periodically to allow the cell to return to normal receptor density.

A more technical version,

Hormones that bind to plasma membrane receptors can induce their effects at very low concentrations because they initiate a cascade or chain reaction.

Hormones affect distant cells by binding to specific receptor proteins in the target cell resulting in a change in cell function. When a hormone binds to the receptor, it results in the activation of a signal transduction pathway. This may lead to cell type-specific responses that include rapid non-genomic effects or slower genomic responses where the hormones acting through their receptors activate gene transcription resulting in increased expression of target proteins.

Thank you for all that information, it is very helpful. my only question left is to work with the hormones rather then have them cancel each other out, do I start on the first day of my period or the first day off my period?

[pom19]

Although Lotus's respond is as usual very informative, but to answer your question on when to take it, it all depends on the individual, some take it during follicular phase, and some during luteal phase. See below for more info on PM:

http://mustgrowbust.com/2012/how-take-pueraria-mirifica

[Lotus]

Thank you for all that information, it is very helpful. my only question left is to work with the hormones rather then have them cancel each other out, do I start on the first day of my period or the first day off my period?

You're welcome, starting on the first day of your period is about average. What program are you considering?, some herbs can be used throughout the cycle, and some only in the first or second half. There's nothing set in stone on which path you take, the exception being is to take it slow and monitor the side effects and adjust.

Good luck.