[anyover88]

So I just learned about an OTC cream that has 1mg estriol and 0.25 mg estradiol (USP) per dose. it semes to be therapeutic for post-menopausal women, much like progesterone cream.

http://www.life-flo.com/women-s-wellness...aretm.html

You know where I'm going with this....

In theory, could someone use this cream alongside progesterone to encourage breast growth while following the luteal and follicular hormone patterns?

I'd like someone knowledgeable like lotus to come and explain why this might be a terrible idea compared to taking something like PM topically or orally or something like hormonal birth control. Could it do something bad like increase the onset of menopause or something in bio females? Is the dosage too low to make any difference?

I read that it seems to benefit post-menopausal women by increasing bone density especially when balanced with progesterone.

I do believe someone should try to balance their hormones holistically instead of artificially increasing them if they don't already have them, but it's good to know if this is a potential option. I'm honestly interested in this myself and will be doing some research.

[Lotus]

Hi anyover,

Yes, using products like life-flo and or progesterone cream (separately) during each phase of the menstrual cycle is standard practice. What I've found is when estrogen and progesterone are introduced at the same time it's said to synergistically up-regulate them, if that's what you meant. A good example is when hormones (sex-steroids) are present in puberty, so in other words, it's conceivable. Incidentally, I've done my own version of PC and E2 source.

Progesterone and estrogen E2 (together) in-quote-"induced proliferation that resulted in sidebranching and alveologenesis," but E+P treatment produced more proliferation sooner and extensive sidebranching and alveologenesis. The exact amounts of E2 (estradiol) and progesterone weren't given. In other words having progesterone combined with E2 produces side-branching of the breasts (outward growth),

function of progesterone receptor isoforms in normal adult mouse mammary gland.
Aupperlee MD1, Haslam SZ.
Author information
Abstract
In normal mouse mammary gland, the mitogenic action of progesterone (P) is mediated by two P receptor (PR) isoforms, PRA and PRB. PRA is predominantly expressed in the adult virgin, and PRB is predominantly expressed during pregnancy. To investigate hormonal regulation of PR isoform expression and isoform-specific functions in vivo, adult ovariectomized BALB/c mice were treated for 3, 5, or 10 d with estrogen (E), P, or estrogen plus progesterone (E+P). Using an immunohistochemical approach with isoform-specific antibodies, we investigated hormonal regulation of PRA and PRB and their functional roles in proliferation and morphogenesis. Significant E-induced proliferation was only observed after 5 d at the distal tips of ducts; there was no sidebranching or alveologenesis. P induced proliferation that resulted in sidebranching and alveologenesis, but E+P treatment produced more proliferation sooner and more extensive sidebranching and alveologenesis. PRA levels were increased by E and decreased by P. Increased PRB levels were induced by treatment with P or E+P and coincided with the formation of alveoli. PRA was the predominant PR isoform expressed during sidebranching, and colocalization of PRA with 5-bromo-2'-deoxyuridine revealed that proliferation of PRA-positive and -negative cells was responsible for P-induced sidebranching. PRB was the predominant PR isoform expressed during alveologenesis, and colocalization of PRB with 5-bromo-2'-deoxyuridine showed that both PRB-positive and -negative cells proliferated during alveolar expansion. These results demonstrate different hormonal regulation of PRA and PRB levels in vivo and suggest that P can induce proliferation through either PRA or PRB via direct and paracrine mechanisms.
http://www.ncbi.nlm.nih.gov/pubmed?filters=&orig_db=PubMed&cmd=Search&term=148%2A%5Bvolume%5D%20AND%202290%5Bpage%5D%20AND%202007%5Bpdat%5D%20AND%20Aupperlee%20MD%5Bauth%5D

[Lotus]

Prolactin stimulates breast growth in the presence of high estrogens, progesterone and estrogen stimulate growth too, and from what I've seen (still needs to be verified) pharma progestins up-regulate IGF-1. However, imo peptides look very promising.




Hormone-Dependent Mammary Gland Development

Hormone-dependent mammary gland development occurs after puberty and results in ductal elongation; recurrent estrous cycles in adulthood trigger side branching; pregnancy enhances side branching and induces alveolo- genesis with lactational differentiation followed by involution at weaning (Brisken 2002). In the late fifties, a series of experiments defined the minimal hormonal requirements for mammary gland development in mice (Nandi 1958) and rats (Lyons 1958). Endocrine ablation was achieved by surgically removing the major sources of reproductive hormones from mature females, the ovaries, which secrete estrogens and progesterone, the pituitary gland, a major source of growth hormone (GH) and prolactin (Prl), and for some experiments the adrenal glands, which release cortisol and precursors of sex steroids (see Fig. 1). Hormone replace- ment in hormone-deprived animals established that additive and sequential treatment with 17-b-estradiol, progesterone, and prolactin in conjunction with cortisol and GH can recapitulate mammary gland development.

http://www.ncbi.nlm.nih.gov/pmc/articles...003178.pdf



   

[krystal3838]

Just checking in on this...I just received my first shipment of Life Flo BiEstro and will be integrating it into my program...updates to follow...smooches to you all.........