[surferjoe2007]

Exercise is great for raising IGF and HGH but it's a temporary spike that doesn't last much longer than the exercise.  Most other things listed most likely only raise them a little, only temporarily and/or only with those with low levels.  It would be good to see studies to quantify them but it doesn't seem likely.  The most likely way to maintain enough IGF and HGH would be to get sufficient nutrition, and beyond that supplements are unlikely to raise it further.

I'd be interested if anyone wants to try out the deer velvet for NBE.  I'm at 1/4 lozenge now instead of 1/2 lozenge to maintain good benefits without any dazed feeling.  Deer velvet seems to be quite strong in spite of the seemingly low dose and would probably be way more effective for IGF-1 than the other methods listed.  Maybe it's because it's cumulative over time, whereas bodybuilders take breaks at the high dose.  Or maybe the effectiveness levels out at the high dose so <1/10th the dose is actually more than <1/10th as strong.  Maybe it's because it contains other less important growth factors besides IGF-1.  And/or maybe it's because the high dose causes incredibly strong effects so a small dose is still pretty darn good.

The thing with HGF is that it's a local hormone causing growth and, I think, repair wherever it is.  IIRC it is especially high near wounds.  It would be nice to see if there's a way to increase it in just the breasts or to increase something that then signals its release in the breasts.  While IGF-1 is good mainly for muscle growth, joint repair and estrogen related tissue growth (breasts, butt, etc.), I think HGF can cause growth in any tissue.  I could be wrong though.  As for heparin even though it increases HGF it reduces cancer risk: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125350/ .

[Miss Mad Scientist]

Right so this is one of my favorite threads on breastnexus

Nice to read about that last Heparin article.

I did some thinking and searching.
Yes locally increasing HGF (Hepatocyte Growth Factor).
This is always possible through the Transpapillary pathway (nipple) after removing the keratin plug (quick swipe with at least 70% alcohol).

link: Transpapillary drug delivery to the breast

So then is the question, how to increase HGF.

Dolobene
Turns out there is a cream containing Heparin and DMSO called Dolobene.
Careful, other creams with this name exist without the heparin and DMSO.
(For those not knowing: DMSO is an amazing carrier into the skin).
The cream/gel is sold in Germany and Eastern Europe over the counter. You can order online from German websites, put them in google translate (for websites) if your not familiar with the German language.
Also, don't get the one with Ibuprofen, NSAID's in general inhibit NBE, the less other ingredients the better.
It costs less than €10 for a 100 ml tube.

Dihexia
Then there is Dihexia, which binds directly to HGF and has the ability to activate its receptor C-met.
Dihexia & HGF link

It is rather expensive, 0.5 grams goes for $60
Dihexia shopping link

I would mix it with DMSO.
500 mg of Dihexia with 30 ml of DMSO would give a nice 16.667 mg/ml solution. Be sure to do that in a glass amber container, as DMSO picks up any molecule in its surrounding. Glass is safe


Mast Cell Degranulation
You can also try to activate your mast cells locally, this releases Heparin and that activates the HGF receptor.
Mast cells are literally in every part of your body (apart from hair and nails).
This can be done by exposing your mast cells to stress. For example, temperature changes like heat.
link: Temperature induces mast cell degranulation

So I have this breast massager that can also give me heat (without massage), bought it on Aliexpres a while ago.
Or Capsaicin cream, capsaicin causes mast cell to degranulate too. And many other ways.


Lotus, this is also why I think your method of ice and cups works.
But then not because of the brown adipose cells that are formed. I came accros several articles on how white adipose tissue sort of become beige adipose tissue (not truly brown), after exposure to cold. But the proposed mechanism was that these cells had to be continuesly stimulated to maintain their beige cell type, or else they go back to being white again.
But maybe this mechanism could possibly explain your growth then.

That was all I could think of at the moment for increasing HGF.
Have a nice weekend everyone!
Love, Ellen

[surferjoe2007]

Doloben and dihexia are drugs and should be approached with extreme caution before use as they may have major unknown effects.

For example a quick search found that dihexia is for nerve growth and acts on nerves rather than where you apply it.  i.e., if applied to the breasts it will still only affect your brain and so on.  While nerve growth might possibly be a good thing, you are majorly messing with your brain.  That's why the website you linked to was a nootropic selling website.  That's why its legal disclaimer says "for laboratory and research use only".  It is illegal to buy these items for personal use.  Lots of people are doing so anyway and experimenting on themselves.  They are also exposing themselves to unknown and potentially serious long term risks on what is basically an untested drug.

Likewise I don't mean for people to actually try out heparin either, because of who-knows-what side effects.  Even for cancer it reduced the risk I think due to reduced metastasis and so might only reduce the risk during cancer treatment.  Long term it may still increase the risk.

While looking for information on HGF its effects seems to be too localized. It goes straight to the nerves or follicles when you try to apply it on top.  Nobody seems to be using it for any kind of body growth legally or illegally.  Unlike IGF-1 which has some popular medical and athletic growth use.

I think low dose IGF-1 is still the thing to look into.  By which I mean deer velvet extract.  See previous posts for more info and good sources (95% are terrible).  If you were going to mess around with unsafe drugs then that would be higher dose IGF-1.  Still not a good idea long term, but not that bad short term.

I have found multiple women using IGF-1 for athletic reasons but they all had near 0% body fat and no breasts to grow.  Though I did find brief posting on just 1 who grew incredibly fast.  And those using deer velvet for NBE used something so dilute that it had almost no IGF-1 in it.  I think a *good* deer velvet extract is something new for NBE that hasn't had much posted on it but could make a big difference.

[surferjoe2007]

So I looked into MK-677, and it seems like great stuff.  25 mg per day, 40-70% increase in IGF-1, plus good HGH increase too.  Superb safety in preliminary studies so far.

I think I touched on DHEA early which gives a smaller increase.

Many other things aren't as effective for raising IGF-1, so always look for studies with a concrete number and make sure the increase isn't some trivial amount.

[sweetorange]

Joe, Ellen, did I understand it well ? Cinnamon applied to the skin makes our skin looks healthier/younger???

https://www.ncbi.nlm.nih.gov/pubmed/22233457

[surferjoe2007]

Yeah... except it doesn't say how much and I couldn't find other studies to give more details.

Instead try looking into retinol, Matrixyl and a scoop of collagen powder.

[sweetorange]

I'm pretty interested in increasing IGF but Ibutamoren is not a very common supplement where I live (Spain) and all my friends who are involved in bodybuilding told me it's not a good idea to consume it. However, for bodyfat issues (I'm at 28% and I'm 24 ! ew  I used to be 22 and my goal is to be at 25 for August) it's ideal to increase it in order to loose some fat . I guess I'll have to do it naturally and my friends suggested me to cut out night snacks , sleep 8-10h daily and supplementing my diet. Now, my question is if eating certain foods or making some changes on my diet would help? Currently my protein intake is higher than usual cause I am building muscle until the end of August (when I will take part in Spartan Super race )

[hannah]

I posted a link about  igf here awhile ago.hope it helps somebody.

http://www.breastnexus.com/showthread.php?tid=25696&pid=199863#pid199863

http://www.breastnexus.com/showthread.php?tid=25696&pid=199863#pid199863

[surferjoe2007]

I'm pretty interested in increasing IGF but Ibutamoren is not a very common supplement where I live (Spain) and all my friends who are involved in bodybuilding told me it's not a good idea to consume it. However, for bodyfat issues (I'm at 28% and I'm 24 ! ew  I used to be 22 and my goal is to be at 25 for August) it's ideal to increase it in order to loose some fat . I guess I'll have to do it naturally and my friends suggested me to cut out night snacks , sleep 8-10h daily and supplementing my diet. Now, my question is if eating certain foods or making some changes on my diet would help? Currently my protein intake is higher than usual cause I am building muscle until the end of August (when I will take part in Spartan Super race )

Interesting.  I know a lot of bodybuilders don't like IGF in general because it's nothing compared to, for example, steroids.  Were they afraid that it would be ineffective or that it would be unsafe?  Or that it's a drug?

[surferjoe2007]

Did a bit more searching on mk-677.  It's mostly popular among bodybuilders.  Women are using it, but most of them are serious bodybuilders with low body and they often use it for weight loss, so it's hard to say if that's preventing any breast gain.  Plus it's hard to find info from more than a month or two of use.  It's popular in both genders for losing fat without losing muscle, a little muscle gain, deep sleep and youthful feel.  In women it also promotes nice hair, skin and nails after a month, with very fast growing hair and nails.  It greatly increases hunger, especially at the beginning.  It causes bloating, especially at the beginning and if you don't limit sodium / raise potassium.  Bloating can be in extremities, and sometimes there's soreness.  Some people mistake the initial hunger (and almost unavoidable eating) and bloating as weight gain, but soon it leads to weight loss.  The dose is 25 mg but many (though not all) women prefer to use less, such as half.  It does seem very powerful, so especially if not using it for bodybuilding a lower dose might be better.

It's a drug that's still being studied and is not yet available for prescription.  Preliminary 1&2 year study show good safety, but long term is uncertain.  https://www.ncbi.nlm.nih.gov/pubmed/18981485  It is likely to have the same risks as low dose IGF-1 and HGH; low, but possible long term risks especially among the elderly.  There might be a lot of fakes; but I found conflicting information on this.

Found a decrease in breast size here but it also came with a large overall fat loss: https://forums.steroid.com/igf-1-lr3-hgh...677-a.html  .  The same woman increased breast size with a couple HGH drugs that did not cause as much weight loss.  Again, whether or not it helps with NBE could be masked with the large fat loss it brings.

Miss Mad Scientest is using MK-677 in her thread: http://www.breastnexus.com/showthread.php?tid=27859&page=3
She says it works really well.  She started at 5 mg and built up, I think to 25 mg.