[Bustyprincess]

So I was doing alil reading on the other forum (nexum) and noticed royal jelly being brought up which kinda confused me because with everything Ive read it says that royal jelly enhances testosterone production(bad for nbe) and in us young people can reduce the effects of estrogen meaning its bad so how come so many use it on the opposite breastnexus? Ive always stayed clear of it for those reasons even though Im post op so cant produce any T

[Lotus]

So I was doing alil reading on the other forum and noticed royal jelly being brought up which kinda confused me because with everything Ive read it says that royal jelly enhances testosterone production(bad for nbe) and in us young people can reduce the effects of estrogen meaning its bad so how come so many use it on the opposite breastnexus? Ive always stayed clear of it for those reasons even though Im post op so cant produce any T

Hi Bustyprincess, I shared this information with Breastnexus in 2017, I don't find royal jelly stimulating testosterone, I've used it with success, also HelloDiDi uses in her program on a regular basis with massive success.
https://breastnexum.com/showthread.php?tid=30169&page=63
Post #629

Hi BN,

I'm listing this post from breastnexum forum, hopefully you'll find it to BEE helpful.  

Looking Great lotus, and sitting tight for that update. This girl needs to know your secret!

right, so sorry for they delay. Tbh, it's a sticky mess but worth the effort for enhanced areolas. It's called " Royal Jelly "....I find applying RJ to areolas to benefit the size and shape of areolas....also breasts if one is willing to manage the mess. Application is sticky..(did I mention that already,lol) use a food grade platstic wrap per area and let it overnight...in the morning nearly all the RJ is absorbed, shower and see results either immediately or throughout the day. This may/or may not work for everyone, it is pollen after all.

As time permits I will be posting new evidence about how IGF-1 (insulin growth factor) and E2 (estradiol) is the next revolution in breast growth.


J Med Food. 2012 Jun;15(6):568-75. doi: 10.1089/jmf.2011.1888. Epub 2012 Apr 2.
Royal jelly increases collagen production in rat skin after ovariectomy.

Park HM1, Cho MH, Cho Y, Kim SY.
Author information
Abstract
Royal jelly (RJ) is a honeybee product that contains proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. RJ has been reported to have antitumor, antibacterial, and wound-healing activities. We previously reported that RJ enhanced the migration of human dermal fibroblasts and altered the levels of cholesterol and sphinganine in an in vitro wound-healing model in addition to regulating skin photoaging following exposure to ultraviolet-B radiation. We established an animal model of skin aging in the context of estrogen deficiency and assessed the antiaging effects of RJ on skin. To establish an in vivo model of skin aging, bilateral ovariectomies were performed in 12-week-old virgin female Sprague-Dawley rats. Induction of osteoporosis was confirmed through two-dimensional images of the trabecular bone in the left femoral necks using microcomputed tomography. The protective effects of RJ ovariectomy-induced skin aging were examined by determining the protein expression of type I procollagen and matrix metalloproteinase (MMP)-1. The collagen content and epidermal thickness of skin tissue were measured by staining techniques. There was a significant difference in weight between sham-operated and ovariectomized groups. Food efficiency ratio did not differ significantly among the groups. The level of procollagen type I protein was increased in the dorsal skin of ovariectomized rats fed with a dietary supplement containing 1% RJ extract, but the level of MMP-1 was not altered. In particular, the amount of collagen recovered was close to the normal level. RJ may protect against skin aging by enhancing collagen production in rats with ovariectomy-induced estrogen deficiency.
PMID: 22468645 PMCID: PMC3359633 DOI: 10.1089/jmf.2011.1888
[Indexed for MEDLINE] Free PMC Article


Bioactive compounds and health-promoting properties of royal jelly: A review
http://medicata.lt/wp-content/uploads/20...review.pdf


Fatty acids derived from royal jelly are modulators of estrogen receptor functions.
Moutsatsou P1, Papoutsi Z, Kassi E, Heldring N, Zhao C, Tsiapara A, Melliou E, Chrousos GP, Chinou I, Karshikoff A, Nilsson L, Dahlman-Wright K.
Author information

Abstract
Royal jelly (RJ) excreted by honeybees and used as a nutritional and medicinal agent has estrogen-like effects, yet the compounds mediating these effects remain unidentified. The possible effects of three RJ fatty acids (FAs) (10-hydroxy-2-decenoic-10H2DA, 3,10-dihydroxydecanoic-3,10DDA, sebacic acid-SA) on estrogen signaling was investigated in various cellular systems. In MCF-7 cells, FAs, in absence of estradiol (E(2)), modulated the estrogen receptor (ER) recruitment to the pS2 promoter and pS2 mRNA levels via only ERβ but not ERα, while in presence of E(2) FAs modulated both ERβ and ERα. Moreover, in presence of FAs, the E(2)-induced recruitment of the EAB1 co-activator peptide to ERα is masked and the E(2)-induced estrogen response element (ERE)-mediated transactivation is inhibited. In HeLa cells, in absence of E(2), FAs inhibited the ERE-mediated transactivation by ERβ but not ERα, while in presence of E(2), FAs inhibited ERE-activity by both ERβ and ERα. Molecular modeling revealed favorable binding of FAs to ERα at the co-activator-binding site, while binding assays showed that FAs did not bind to the ligand-binding pocket of ERα or ERβ. In KS483 osteoblasts, FAs, like E(2), induced mineralization via an ER-dependent way. Our data propose a possible molecular mechanism for the estrogenic activities of RJ's components which, although structurally entirely different from E(2), mediate estrogen signaling, at least in part, by modulating the recruitment of ERα, ERβ and co-activators to target genes.


Royal jelly has estrogenic effects in vitro and in vivo.
Mishima S1, Suzuki KM, Isohama Y, Kuratsu N, Araki Y, Inoue M, Miyata T.

Author information
Abstract
Royal jelly (RJ) from honeybees (Apis mellifera) is traditionally thought to improve menopausal symptoms. The potential estrogenic activities of RJ were investigated using various approaches. RJ competed for binding of 17beta-estradiol to the human estrogen receptor alpha and beta but its affinities were weak compared with diethylstilbestrol and phytoestrogens. The reporter gene expression assays suggested that 0.1-1 mg/ml RJ activated estrogen receptors, leading to enhanced transcription of a reporter gene through an estrogen-responsive element. 1 mg/ml RJ stimulated the mRNA expression of estrogen-responsive pS2 and vascular endothelial growth factor (VEGF) by increasing gene transcription in MCF-7 cells. Treatment with RJ at concentrations ranging from 0.5 to 1 mg/ml enhanced MCF-7 cell proliferation, but concomitant treatment with 1 microM tamoxifen blocked this effect. In vivo studies using ovariectomized rats showed that 17beta-estradiol (20 mg/kg, s.c.) treatment restored VEGF expression in both uterus and brain, whereas RJ (1 g/kg, s.c.) restored it in uterus but not in brain. These findings provide evidence that RJ has estrogenic activities through interaction with estrogen receptors followed by endogenous gene expressions.
PMID: 15946813  DOI: 10.1016/j.jep.2005.04.012


Effect of royal jelly ingestion for six months on healthy volunteers.

Morita H1, Ikeda T, Kajita K, Fujioka K, Mori I, Okada H, Uno Y, Ishizuka T.

Author information

Abstract
BACKGROUND:
Royal jelly is a widely ingested supplement for health, but its effects on humans are not well known. The objective was to evaluate the effects of long-term royal jelly ingestion on humans.
METHODS:
We conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention.
RESULTS:
Thirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x10⁶/μL for the RJ group vs. -0.01x10⁶/μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276).
CONCLUSIONS:
Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects.

[Bustyprincess]

So I was doing alil reading on the other forum and noticed royal jelly being brought up which kinda confused me because with everything Ive read it says that royal jelly enhances testosterone production(bad for nbe) and in us young people can reduce the effects of estrogen meaning its bad so how come so many use it on the opposite breastnexus? Ive always stayed clear of it for those reasons even though Im post op so cant produce any T

Hi Bustyprincess, I shared this information with Breastnexus in 2017, I don't find royal jelly stimulating testosterone, I've used it with success, also HelloDiDi uses in her program on a regular basis with massive success.
https://breastnexum.com/showthread.php?tid=30169&page=63
Post #629

Hi BN,

I'm listing this post from breastnexum forum, hopefully you'll find it to BEE helpful.  

Looking Great lotus, and sitting tight for that update. This girl needs to know your secret!

right, so sorry for they delay. Tbh, it's a sticky mess but worth the effort for enhanced areolas. It's called " Royal Jelly "....I find applying RJ to areolas to benefit the size and shape of areolas....also breasts if one is willing to manage the mess. Application is sticky..(did I mention that already,lol) use a food grade platstic wrap per area and let it overnight...in the morning nearly all the RJ is absorbed, shower and see results either immediately or throughout the day. This may/or may not work for everyone, it is pollen after all.

As time permits I will be posting new evidence about how IGF-1 (insulin growth factor) and E2 (estradiol) is the next revolution in breast growth.


J Med Food. 2012 Jun;15(6):568-75. doi: 10.1089/jmf.2011.1888. Epub 2012 Apr 2.
Royal jelly increases collagen production in rat skin after ovariectomy.

Park HM1, Cho MH, Cho Y, Kim SY.
Author information
Abstract
Royal jelly (RJ) is a honeybee product that contains proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. RJ has been reported to have antitumor, antibacterial, and wound-healing activities. We previously reported that RJ enhanced the migration of human dermal fibroblasts and altered the levels of cholesterol and sphinganine in an in vitro wound-healing model in addition to regulating skin photoaging following exposure to ultraviolet-B radiation. We established an animal model of skin aging in the context of estrogen deficiency and assessed the antiaging effects of RJ on skin. To establish an in vivo model of skin aging, bilateral ovariectomies were performed in 12-week-old virgin female Sprague-Dawley rats. Induction of osteoporosis was confirmed through two-dimensional images of the trabecular bone in the left femoral necks using microcomputed tomography. The protective effects of RJ ovariectomy-induced skin aging were examined by determining the protein expression of type I procollagen and matrix metalloproteinase (MMP)-1. The collagen content and epidermal thickness of skin tissue were measured by staining techniques. There was a significant difference in weight between sham-operated and ovariectomized groups. Food efficiency ratio did not differ significantly among the groups. The level of procollagen type I protein was increased in the dorsal skin of ovariectomized rats fed with a dietary supplement containing 1% RJ extract, but the level of MMP-1 was not altered. In particular, the amount of collagen recovered was close to the normal level. RJ may protect against skin aging by enhancing collagen production in rats with ovariectomy-induced estrogen deficiency.
PMID: 22468645 PMCID: PMC3359633 DOI: 10.1089/jmf.2011.1888
[Indexed for MEDLINE] Free PMC Article


Bioactive compounds and health-promoting properties of royal jelly: A review
http://medicata.lt/wp-content/uploads/20...review.pdf


Fatty acids derived from royal jelly are modulators of estrogen receptor functions.
Moutsatsou P1, Papoutsi Z, Kassi E, Heldring N, Zhao C, Tsiapara A, Melliou E, Chrousos GP, Chinou I, Karshikoff A, Nilsson L, Dahlman-Wright K.
Author information

Abstract
Royal jelly (RJ) excreted by honeybees and used as a nutritional and medicinal agent has estrogen-like effects, yet the compounds mediating these effects remain unidentified. The possible effects of three RJ fatty acids (FAs) (10-hydroxy-2-decenoic-10H2DA, 3,10-dihydroxydecanoic-3,10DDA, sebacic acid-SA) on estrogen signaling was investigated in various cellular systems. In MCF-7 cells, FAs, in absence of estradiol (E(2)), modulated the estrogen receptor (ER) recruitment to the pS2 promoter and pS2 mRNA levels via only ERβ but not ERα, while in presence of E(2) FAs modulated both ERβ and ERα. Moreover, in presence of FAs, the E(2)-induced recruitment of the EAB1 co-activator peptide to ERα is masked and the E(2)-induced estrogen response element (ERE)-mediated transactivation is inhibited. In HeLa cells, in absence of E(2), FAs inhibited the ERE-mediated transactivation by ERβ but not ERα, while in presence of E(2), FAs inhibited ERE-activity by both ERβ and ERα. Molecular modeling revealed favorable binding of FAs to ERα at the co-activator-binding site, while binding assays showed that FAs did not bind to the ligand-binding pocket of ERα or ERβ. In KS483 osteoblasts, FAs, like E(2), induced mineralization via an ER-dependent way. Our data propose a possible molecular mechanism for the estrogenic activities of RJ's components which, although structurally entirely different from E(2), mediate estrogen signaling, at least in part, by modulating the recruitment of ERα, ERβ and co-activators to target genes.


Royal jelly has estrogenic effects in vitro and in vivo.
Mishima S1, Suzuki KM, Isohama Y, Kuratsu N, Araki Y, Inoue M, Miyata T.

Author information
Abstract
Royal jelly (RJ) from honeybees (Apis mellifera) is traditionally thought to improve menopausal symptoms. The potential estrogenic activities of RJ were investigated using various approaches. RJ competed for binding of 17beta-estradiol to the human estrogen receptor alpha and beta but its affinities were weak compared with diethylstilbestrol and phytoestrogens. The reporter gene expression assays suggested that 0.1-1 mg/ml RJ activated estrogen receptors, leading to enhanced transcription of a reporter gene through an estrogen-responsive element. 1 mg/ml RJ stimulated the mRNA expression of estrogen-responsive pS2 and vascular endothelial growth factor (VEGF) by increasing gene transcription in MCF-7 cells. Treatment with RJ at concentrations ranging from 0.5 to 1 mg/ml enhanced MCF-7 cell proliferation, but concomitant treatment with 1 microM tamoxifen blocked this effect. In vivo studies using ovariectomized rats showed that 17beta-estradiol (20 mg/kg, s.c.) treatment restored VEGF expression in both uterus and brain, whereas RJ (1 g/kg, s.c.) restored it in uterus but not in brain. These findings provide evidence that RJ has estrogenic activities through interaction with estrogen receptors followed by endogenous gene expressions.
PMID: 15946813  DOI: 10.1016/j.jep.2005.04.012


Effect of royal jelly ingestion for six months on healthy volunteers.

Morita H1, Ikeda T, Kajita K, Fujioka K, Mori I, Okada H, Uno Y, Ishizuka T.

Author information

Abstract
BACKGROUND:
Royal jelly is a widely ingested supplement for health, but its effects on humans are not well known. The objective was to evaluate the effects of long-term royal jelly ingestion on humans.
METHODS:
We conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention.
RESULTS:
Thirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x10⁶/μL for the RJ group vs. -0.01x10⁶/μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276).
CONCLUSIONS:
Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects.

Hi Lotus I was hoping you would comment! Ive always wanted to try it but got super scared off by the fact that certain things I read online state it reduces estrogen effects in young people and increases testosterone production via the testes(though Im post op so couldnt do that) but more concerned about the "reducing estrogen effects" part is there any reason there is so much conflicting info on google search? Have your or HelloDiDi had this effect of estrogen reduction with Royal Jelly? Hope you are well <3 here is a link to what I found 
"Supplementing royal jelly can enhance testicular testosterone production. Animal research suggests it is able to increase estrogen in post-menopausal animals. Royal jelly may also reduce the effects of estrogen in youth. These hormonal effects are unreliable and difficult to predict." 
https://examine.com/supplements/royal-jelly/
Also is its only effect enhanced areolas? If so I already have big areolas from starting hormones (bio estrogen and bio progesterone) as a young teen so definitely dont want them bigger. I will read everything you have written x

[Lotus]

Hi Bustyprincess, I don't think royal jelly would be a good fit for you if you're areolas big. With zero T production you have and the small impact to T the authors of examine said RJ could cause I wouldn't be concern if I were you. Did you have another purpose for RJ in mind? What I do worry about for those who've had GCS (gender confirmation surgeries) like us is bone loss. I broke my ankle earlier this year like it was nothing, but that's a conversation for another day. 

[Bustyprincess]

Hi Bustyprincess, I don't think royal jelly would be a good fit for you if you're areolas big. With zero T production you have and the small impact to T the authors of examine said RJ could cause I wouldn't be concern if I were you. Did you have another purpose for RJ in mind? What I do worry about for those who've had GCS (gender confirmation surgeries) like us is bone loss. I broke my ankle earlier this year like it was nothing, but that's a conversation for another day. 

Oh ok! Thank you for letting me know then!   I just remember seeing it in quite a few Japanese/Korean breast supplements along with other ingredients so thought maybe it would help with breast growth but if its only areolas then I definitely dont need it, yeh that is definitely a thing for us post op girls to watch out for! Luckily I annually get my bio estrogen pellet implant and take bio progesterone daily so should be fine my endocrinologist keeps an eye on everything even my vitamin levels as Im practically vego. Sorry to hear you broke your ankle ouch! Ive broken quite a few bones myself not fun 

[Bustyprincess]

Hey Lotus hoping you see this! I tried private msging you twice but it doesnt seem to go through says I have maxed out my messages even though I deleted them all, I would absolutely love your input on my current routine on my thread if there is anything I should add! I remember reading something you posted about vitamins I think and I cannot find it I am already taking D3, vit C and magnesium. Fingers crossed you see this!  :D