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New growth method? Fatty acid penetration into human skin ex vivo - A theory

#1

https://pubmed.ncbi.nlm.nih.gov/28253633...n%20layers.

Above is a link to a study that shows Linoleic fatty acid directly absorbs into the full dermis. Oddly enough, Linoleic fatty acid also directly absorbed by adipose issue. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373086/

THE FOLLOWING IS COMPLETELY HYPOTHETICAL AND I CANNOT RECCOMEND ANYONE DOES THIS


In theory if someone were to perform the following using the cups found in vacuum breast expansion devices:

  1. Add sunflower seed oil to the cup prior to inserting the breast.
  2. Pull a slight vacuum just enough to expand the pores of the epidermis on the breast using suction to hold the breast in place when submerged in the fatty acid
  3. Leave breast in cup for a set amount of time to allow for absorption (until full dermis saturation occurs).

The closest off the shelf item to pure Linoleic fatty acid is Sunflower Oil:
Sunflower oil contains approximately 15% saturated, 85% unsaturated fatty acid and consisting of 14–43% oleic and 44–75% linoleic acids in its unsaturated fatty acid content.

https://www.ncbi.nlm.nih.gov/pmc/article...%20content.

This theory started after reading this https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243074/ Topical emollient therapy in the management of severe acute malnutrition in children under two: A randomized controlled clinical trial in Bangladesh

This study proves that topical sunflower seed oil does lead to weight gain (not a significant amount due to the study consisting of only 10 days but still a gain). I would imagine that use of this would lead to more substantial growth than using vacuum therapy alone.

Please be aware of any dangers when experimenting with your body. Only do so if you are comfortable with the risk and decide to proceed forward with any protocol you read.
Please share your thoughts.
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#2

Why would any weight gain go to the breasts though, rather than being general weight gain?
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#3

Because it is topically applied, not a pill.
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#4

Oh I see. Well it's quite interesting then, although the study quoted above did not lead to significant results.
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#5

Safflower oil will be high in linoleic acid more consistently than sunflower seed oil, because most sunflower seed oil now is genetically modified to comprise mostly oleic acid. 
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#6

Welll holy shit…. it fucking worked. I have gained 1.5 lbs body weight (really negligible) and I want to say 200cc (little over a cup) in each breast. I used high oleic concretion at 95%.oleic acid stimulates Ppar-gamma is said to activate maturation of adipocytes. And I can’t really think of any other reason it worked.
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#7

Thanks for your update - sounds great! I hope you can continue to keep us informed.
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#8

It would be nice to get an update on this. 
From the start of the thread, to the first update, about 3.5 months passed, with about 200cc's of size gained in that time... All things considered, this looks like a much easier method of breast enhancement than some of the other methods on this site. Faster, too.
I think maybe this thread should be crossposted or moved to the pumping forum, to get more eyes on this and to get more people trying it out. It's based on pumping, after all. Moreover, if this method works, it would be a far superior way of breast enhancement by pumping than noogling or the evebra...

OP, I think you might have figured out how to achieve localized weight gain... Basically a non-surgical fat-transfer, except it's not your own fat. People pay a lot of money for that  kinda stuff.
Another thought: this could be used on the butt, as well. To whom it may concern...


I have done some digging on different types of fatty acids and their effect on fat cells... but I'm not sure what to make of it. (I don't have a background in this.) 
In short, the Peroxisome Proliferator-Activated Receptor γ (Gamma), or PPARγ, is very important in turning the precursor cells into actual fat cells...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549902/
"Peroxisome Proliferator-Activated Receptor γ in White and Brown Adipocyte Regulation and Differentiation"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110914/
"Deciphering the Roles of PPARγ in Adipocytes via Dynamic Change of Transcription Complex"


So far, so good. So what do the different kinds of fatty acids do to PPARγ?

https://www.endocrine-abstracts.org/ea/0049/ea0049ep642
"Dietary intake of linoleic, linolenic, oleic, and arachidonic acid PPAR-gamma gene expression in visceral and subcutaneous adipose tissue among healthy subjects"
"Results: The PPAR-gamma expression in visceral adipose tissue among non-obese subjects was correlated with oleic acid (r=−0.417, P=0.007) and linoleic acid (r=−0.401, P=0.009). Were seen significant correlations between subcutaneous adipose tissue PPAR-gamma expression and linoleic acid (r=−0.310, P=0.049) among non-obese subjects..."


"Conclusions: PPAR-gamma gene expression was negatively correlated with linoleic and oleic acids among non-obese and obese subjects."

So linoleic, linolenic, oleic, and arachidonic acid somewhat inhibit PPARγ expression... whereas the oil most associated with activating PPARγ is CLA, or conjugated linoleic acid... which is heavily found in safflower oil, already mentioned in this thread. (Linoleic acid and conjugated linoleic acid are different things.)

https://pubmed.ncbi.nlm.nih.gov/15362034/
"Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease"

But this is where I get stumped, because CLA is, apparently, well-known as a weight loss product. Burning fat, preventing fat buildup etc. 
So it might not be a good choice, after all.

Going by this study, it might not matter too much, as simply gaining weight seems to create new fat cells:

https://pubmed.ncbi.nlm.nih.gov/29991030/
"...A decrease in body weight only changes fat cell size (becoming smaller), whereas an increase in body weight causes elevation of both fat cell size and number in adults..."

So as long as whatever oil and therefore type of fat in use is a) healthy and b) doesn't prevent weight gain, it should be fine. Consistent application of the method should result in localized weight gain and therefore, breast enhancement.
But I'm not a scientist or doctor, so do take this with a grain of salt.
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#9

No disrespect intended, but anyone reading this should look up what “statistical significance” means. It’s an extremely important thing to understand if you’re trying to interpret studies as a layperson. I’m happy to see people experiment with new ideas that are very low risk, like this one, but the study did not show that rubbing oil on the skin leads to weight gain. OP was also pumping, not just applying oil. OP, if you’re reading this, It would be interesting to know how often, how much, and how hard you pumped, and whether the size increase stuck around long term.
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