[tuula]

http://www.ncbi.nlm.nih.gov/pubmed/17585183

Assessment of fertility and reproductive toxicity in adult female mice after long-term exposure to Pueraria mirifica herb.
Jaroenporn S, Malaivijitnond S, Wattanasirmkit K, Watanabe G, Taya K, Cherdshewasart W.
Source

Interdepartment of Physiology, Faculty of Graduate School, Chulalongkorn University, Bangkok, Thailand.
Abstract

The present study investigated the effects of long-term administration of Pueraria mirifica (PM) at non-toxic doses on the ovarian function and fertility of adult female mice based on evaluation of hematological and biochemical parameters. Female mice were divided into 4 groups (36 mice/group). Groups 1-3 were orally treated with a dose of 0 (PM-0), 10 (PM-10) or 100 mg/kg BW/day PM (PM-100), and group 4 was subcutaneously injected with 200 mug/kg BW/day of synthetic estrogen diethylstilbestrol (DES). The treatment schedule was separated into treatment and post-treatment periods. The duration of each period was 8 weeks. The PM-10 mice exhibited regular estrous cycles, while the PM-100 and DES treatments induced prolonged estrous cycles. Although no changes were observed in the uterus and ovary weights of the mice after the PM-100 and DES treatments, hyperplasia of the uterine endothelium and a decrease in the number of growing ovarian follicles were detected. The changes in the ovarian histologies of the PM-100 and DES mice were related to reductions in the levels of LH and FSH, which subsequently caused a decrease in mating efficiency. Once the PM mice were able to copulate, they were capable of successfully becoming pregnant and mothering offspring. No abnormalities were observed in the external morphologies and reproductive organ weights of the 50-day-old offspring. In conclusion, our results suggest that long-term exposure to 100 mg/kg BW of PM has adverse effects on the mating efficiency and reproduction of adult female mice and that administration of 10 mg/kg BW of PM does not induce any changes in the hypothalamic-pituitary-ovarian-uterine axis.

[Isabelle]

Hi Chocogirl,

For a body weight (BW) of 50 kg (110 lbs), this is about 5,000 mg PM. Only Chrissie on the male forum went that high, and she reported a decrease in "mating efficiency" too.

[miabella]

There are studies on every thing on this planet...one side says it will kill you or cause disease or cancer, the other side is beneficial. Best thing to do is keep up your 6 month check-ups at the gyno, go slow and listen to your body. All of these herbs have many benefits other than growing breasts.

[tuula]

http://resources.metapress.com/pdf-preview.axd?code=f6221184631n82rl&size=largest

PM can suppress ovulation by lowering serum level of gonadotropins.


I am still wondering when it s best to take PM if someone wants to keep ovulation:
days 1-14 and then ovulation ;at this case it seems that you raise estrogen levels on days 1-6 when estrogen is supposed to be low-so are you messing with gonadotropins in that case?
or

days 7-13 and then 18-24 as GorgeousBlonde so you follow your cycles natural rise of estrogen?

in order to see progress do you need to offer estrogen when it is naturally low ,even though you disturb your cycle and ovulation ,
or
raise estrogen levels when they are naturally high?

I m just trying to understand how PM works and if possible don t mess with my cycle and fertility.

[surferjoe2007]

That's also what the study says, for the ~5,000 mg amount. The effect comes from increased estrogen and works the same way as taking estrogen for birth control works.