Hi.
I respect and admire your precautionary approach. There is something many of us really, really want here

. I have definitely a thing or two about what my body does with the information it is given. Most supplements can be beneficial, non-beneficial, or even disadvantageous. It depends on the dose, body, intention, etc. I would say the advice about better quality of MSM is worth serious consideration. Our experiences with it, are positive and "negative." It seems like sometimes it is really helpful and sometimes, it cause adverse affects like the terrible headaches my Mother had during one period she was taking. Other times, it gave her benefits. That is why it's a good idea to monitor how your body reacts, while carefully taking such a supplement and also hoping for the best. Sometimes, I think I have experienced the acne breakouts with MSM. This is very common because it detoxes the body (also causing headaches and stomach cleansing, if you catch my meaning. My Mother takes pharmaceuticals that can build up in the body and her heachaches at that time, were probably to do with her body recalibrating from toxic side affects of chemical medicines).
For example, with one NBE regimen I tried, I added kelp powder for iodine as recommended. But I didn't realize how sensitive my thryroid could be. So I had to get rid of it because I was so sleepy, I could hardly function, even with the teeniest dose. My Mother took the bottle and liked it just fine. But I can eat seaweed no problem.
Recently, I found an old bottle of Black Cohosh. I thought, why not just throw one extra capsule into my routine-- herbs lose potency over time anyway. Well, within a week, my legs were about 3 times their normal size and similar to when I once took a recommended dose of protein (which was too much for me personally), my lower body bulked up like crazy. It was just a very specific region of my top half that I was hoping to add mass to. Hahahaha. Luckily, the body can be very adjustable in crazy cases like that. I square butt and kankles are not what I was aiming for!
Anyway, every body is different. It's not that these particular supps are just good or bad. Body chemistry, at certain periods, count. I think I took Black cohosh in the past without incident. Now I just rub it on my chest--no problem! Just pay attention to what your body does, ramp slowly, and try to use good quality ingredients or better. I usually get my supps online from Vitacost, Swanson's, or Dr. Vita. I read the ingredients. But there is excellent bulk MSM at Natural Grocers/Vitamin Cottage if you have one near by.
Good luck, Chama! We all in this together.