[Tanya Marie Squirrel]

http://onlinelibrary.wiley.com/doi/10.11...101.x/full

Interesting article.....perhaps in the future, they can perfect it in humans

[Dianna1395]

Tanya,
Don't we wish! But I think this is the analogue to Androgen Insensitivity Syndrome in humans.
There are a lot of women walking around out there who are actually MEN. They just don't / won't know it.

::sigh:: They have NO idea how lucky they are.
It's back to, how do you make the body transform? Until we can re-grow our body, I think we're stuck. :-(

But hope does spring eternal!
-Jean

[jannet.duff]

http://onlinelibrary.wiley.com/doi/10.11...101.x/full

Interesting article.....perhaps in the future, they can perfect it in humans

It makes you wonder if we can just find somthing to cause the analogue to Androgen Insensitivity Syndrome in a herb !! ( re: turn off our DHT receptors )

[Tanya Marie Squirrel]

http://onlinelibrary.wiley.com/doi/10.11...101.x/full

Interesting article.....perhaps in the future, they can perfect it in humans

It makes you wonder if we can just find somthing to cause the analogue to Androgen Insensitivity Syndrome in a herb !! ( re: turn off our DHT receptors )

Lol we have that....sort of..just not immediately permanent.....for now..i.e. daily doses.

[WantAPair]

We used to have a dog, Sammy. We got her Dec. 1980 when she was a puppy. We checked and found that she was a boy dog and when she peed, she'd lift her leg, just like a boy dog. After a few weeks or so, my neighbor/future brother-in-law and former forest ranger type and John Denver lover came over to look at Sammy and said, we'd better thing about changing the dog's name, because it's a girl dog! We checked again and, sure enough, she was a girl!! So, we called her, Samantha. A year later (1982), she had 6 pups on Valentine's day!

[Dianna1395]

WAP,
Lifting the leg is supposedly a learned behavior. Funny, because my mom has a Chihuahua/Terrier mix that has ALWAYS lifted its leg, and yes, she's female.

I wonder if it's also a dominance thing? That little runt is definitely cock of the walk...

-Jean

[Dianna1395]

http://onlinelibrary.wiley.com/doi/10.11...101.x/full

Interesting article.....perhaps in the future, they can perfect it in humans

It makes you wonder if we can just find somthing to cause the analogue to Androgen Insensitivity Syndrome in a herb !! ( re: turn off our DHT receptors )

That would be an excellent idea...
Can we get a "locking" substance what would do it?
1. Bicalutamide, IIRC, is an antagonist to androgen receptors. But it then releases, leaving the receptor open for future use.
2. DHT and scalp hair follicles give us an example of a hormone that locks on and doesn't release from a receptor. Even Minoxidil is merely a vasodilator, just increases circulation - it doesn't unlock the DHT from the hair follicle.

Do we have any good chemists who could analyze the lock mechanism on the follicle+DHT and make a variant of Bicalutamide that would "lock" to the Androgen receptors, permanently?

Also a question, tied to tucking, relevant here:
I was reading the prolonged tucking reduces T by "killing" the leydig cells and basically ends T production in the testicles.
This is 24/7 for weeks to months, which causes testicular atrophy.

Anyone have long-term, documented changes from tucking alone? Maybe a DHT/T/E/Progesterone split?

Putting all the techniques together would likely make fast and awe-inspiring progress....

-Jean

[jannet.duff]

http://onlinelibrary.wiley.com/doi/10.11...101.x/full

Interesting article.....perhaps in the future, they can perfect it in humans

It makes you wonder if we can just find somthing to cause the analogue to Androgen Insensitivity Syndrome in a herb !! ( re: turn off our DHT receptors )

That would be an excellent idea...
Can we get a "locking" substance what would do it?
1. Bicalutamide, IIRC, is an antagonist to androgen receptors. But it then releases, leaving the receptor open for future use.
2. DHT and scalp hair follicles give us an example of a hormone that locks on and doesn't release from a receptor. Even Minoxidil is merely a vasodilator, just increases circulation - it doesn't unlock the DHT from the hair follicle.

Do we have any good chemists who could analyze the lock mechanism on the follicle+DHT and make a variant of Bicalutamide that would "lock" to the Androgen receptors, permanently?

Also a question, tied to tucking, relevant here:
I was reading the prolonged tucking reduces T by "killing" the leydig cells and basically ends T production in the testicles.
This is 24/7 for weeks to months, which causes testicular atrophy.

Anyone have long-term, documented changes from tucking alone? Maybe a DHT/T/E/Progesterone split?

Putting all the techniques together would likely make fast and awe-inspiring progress....

-Jean

I did read one report that indicated that our hair folicals are not dead, but just dormant. But it was difficult to release the DHT from the folicals to wake them up again.

[WantAPair]

WAP,
Lifting the leg is supposedly a learned behavior. Funny, because my mom has a Chihuahua/Terrier mix that has ALWAYS lifted its leg, and yes, she's female.

I wonder if it's also a dominance thing? That little runt is definitely cock of the walk...

-Jean

That be so, but she DEFINITELY had a dick the first few weeks, or so.

[Tanya Marie Squirrel]

WAP,
Lifting the leg is supposedly a learned behavior. Funny, because my mom has a Chihuahua/Terrier mix that has ALWAYS lifted its leg, and yes, she's female.

I wonder if it's also a dominance thing? That little runt is definitely cock of the walk...

-Jean

Perhaps a dominace thing. My two golden retrievers ( certified female) were horsing around with each other at the campground this summer . Anne , who usually takes the lead when they run free, totally flabberghasted me, by mounting her sister, like a male! Of course, i discouraged that behavior real quick. ...lol perhaps my anne is a female to male transsexual canine??? :p

What gets me though, is her tail usually hangs down, which is sign of submission, i have been told, yet she is the more dominant of the two. She is more demure and serious, compared to her sister.